Cancer-associated mutation and beyond: The emerging biology of isocitrate dehydrogenases in human disease

Isocitrate dehydrogenases (IDHs) are critical metabolic enzymes that catalyze the oxidative decarboxylation of isocitrate to α-ketoglutarate (αKG), NAD(P)H, and CO(2). IDHs epigenetically control gene expression through effects on αKG-dependent dioxygenases, maintain redox balance and promote anaple...

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Detalles Bibliográficos
Autores principales: Tommasini-Ghelfi, Serena, Murnan, Kevin, Kouri, Fotini M., Mahajan, Akanksha S., May, Jasmine L., Stegh, Alexander H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530995/
https://www.ncbi.nlm.nih.gov/pubmed/31131326
http://dx.doi.org/10.1126/sciadv.aaw4543

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