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Low serum bilirubin, albumin, and uric acid levels in patients with Crohn's disease

Serum concentrations of bilirubin, albumin, and uric acid (UA) play important roles in controlling oxidative stress. Until now, there are few researches related to the relationship between oxidative stress and Crohn's disease (CD); furthermore, no such study has been reported from China. Our ai...

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Autores principales: Su, Qisheng, Li, Xiaohong, Mo, Wuning, Yang, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531115/
https://www.ncbi.nlm.nih.gov/pubmed/31083269
http://dx.doi.org/10.1097/MD.0000000000015664
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author Su, Qisheng
Li, Xiaohong
Mo, Wuning
Yang, Zheng
author_facet Su, Qisheng
Li, Xiaohong
Mo, Wuning
Yang, Zheng
author_sort Su, Qisheng
collection PubMed
description Serum concentrations of bilirubin, albumin, and uric acid (UA) play important roles in controlling oxidative stress. Until now, there are few researches related to the relationship between oxidative stress and Crohn's disease (CD); furthermore, no such study has been reported from China. Our aim was to evaluate serum bilirubin, albumin, and UA levels in CD patients and relate them to disease activity. Seventy-one patients diagnosed with CD and 125 sex- and age-matched healthy individuals were retrospectively analyzed during the same period. Clinical characteristics and laboratory parameters were analyzed in CD patients and healthy control groups. Serum levels of bilirubin, albumin, and UA in patients with CD were significantly lower than those in the healthy control group. Correlation analysis demonstrated that serum concentrations of total bilirubin, direct bilirubin, indirect bilirubin, albumin, and UA were negatively related to disease activity in patients with CD (r = −0.620, P < .001; r = −0.304, P < .05; r = −0.623, P < .001; r = −0.408, P < .01; and r = −0.296, P < .05; respectively). Serum bilirubin, albumin and UA levels were significantly lower in CD patients, suggesting potential correlations between serum bilirubin, albumin, and UA levels and disease activity in CD patients. In addition, the noninvasive biochemical index may be potential markers for assessing the disease activity of patients with CD.
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spelling pubmed-65311152019-06-25 Low serum bilirubin, albumin, and uric acid levels in patients with Crohn's disease Su, Qisheng Li, Xiaohong Mo, Wuning Yang, Zheng Medicine (Baltimore) Research Article Serum concentrations of bilirubin, albumin, and uric acid (UA) play important roles in controlling oxidative stress. Until now, there are few researches related to the relationship between oxidative stress and Crohn's disease (CD); furthermore, no such study has been reported from China. Our aim was to evaluate serum bilirubin, albumin, and UA levels in CD patients and relate them to disease activity. Seventy-one patients diagnosed with CD and 125 sex- and age-matched healthy individuals were retrospectively analyzed during the same period. Clinical characteristics and laboratory parameters were analyzed in CD patients and healthy control groups. Serum levels of bilirubin, albumin, and UA in patients with CD were significantly lower than those in the healthy control group. Correlation analysis demonstrated that serum concentrations of total bilirubin, direct bilirubin, indirect bilirubin, albumin, and UA were negatively related to disease activity in patients with CD (r = −0.620, P < .001; r = −0.304, P < .05; r = −0.623, P < .001; r = −0.408, P < .01; and r = −0.296, P < .05; respectively). Serum bilirubin, albumin and UA levels were significantly lower in CD patients, suggesting potential correlations between serum bilirubin, albumin, and UA levels and disease activity in CD patients. In addition, the noninvasive biochemical index may be potential markers for assessing the disease activity of patients with CD. Wolters Kluwer Health 2019-05-13 /pmc/articles/PMC6531115/ /pubmed/31083269 http://dx.doi.org/10.1097/MD.0000000000015664 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Research Article
Su, Qisheng
Li, Xiaohong
Mo, Wuning
Yang, Zheng
Low serum bilirubin, albumin, and uric acid levels in patients with Crohn's disease
title Low serum bilirubin, albumin, and uric acid levels in patients with Crohn's disease
title_full Low serum bilirubin, albumin, and uric acid levels in patients with Crohn's disease
title_fullStr Low serum bilirubin, albumin, and uric acid levels in patients with Crohn's disease
title_full_unstemmed Low serum bilirubin, albumin, and uric acid levels in patients with Crohn's disease
title_short Low serum bilirubin, albumin, and uric acid levels in patients with Crohn's disease
title_sort low serum bilirubin, albumin, and uric acid levels in patients with crohn's disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531115/
https://www.ncbi.nlm.nih.gov/pubmed/31083269
http://dx.doi.org/10.1097/MD.0000000000015664
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