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A clinical research on the potential pathogenesis of somatic cancer related cerebral venous sinus thrombosis
To investigate the pathogenesis of somatic solid cancer-related cerebral venous sinus thrombosis (CVST). A total of 174 patients with CVST were recruited from the hospital between January 2006 and December 2017 and divided into two groups: (1) somatic cancer-related CVST group, defined as active som...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531122/ https://www.ncbi.nlm.nih.gov/pubmed/31083150 http://dx.doi.org/10.1097/MD.0000000000015134 |
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author | Xian, Ziqiang Chen, Yicong Chen, Li Lu, Qiuhong Huang, Gelun Qin, Qixiong Zeng, Jinsheng Liang, Zhijian |
author_facet | Xian, Ziqiang Chen, Yicong Chen, Li Lu, Qiuhong Huang, Gelun Qin, Qixiong Zeng, Jinsheng Liang, Zhijian |
author_sort | Xian, Ziqiang |
collection | PubMed |
description | To investigate the pathogenesis of somatic solid cancer-related cerebral venous sinus thrombosis (CVST). A total of 174 patients with CVST were recruited from the hospital between January 2006 and December 2017 and divided into two groups: (1) somatic cancer-related CVST group, defined as active somatic solid cancer patients with acute CVST; (2) cancer group (CG), defined as active somatic solid cancer patients without CVST. The cancer group patients were age and gender-matched somatic cancer-related CVST group patients. In addition, the types and amount distribution of cancer in cancer group were also matched with somatic cancer-related CVST group patients. Compared to cancer group patients, somatic cancer-related CVST group patients had more intracranial metastasis, a higher platelet count, higher plasma D-dimer, carcinoembryonic antigen (CEA) and cancer antigen (CA) 125 levels, a greater platelet to lymphocyte ratio (PLR), and a greater platelet to neutrophil ratio (PNR). The risk for CVST in somatic cancer-related CVST group patients increased independently by 0.7% (odds ratio [OR] 1.007; 95% confidence interval [CI] 1.000, 1.015; P = .047) with a 1 ng/ml increase in D-dimer levels, by 4.6% (OR 1.046; 95% CI 1.011, 1.083; P = .010) with a 1 U/ml increase in CEA, by 2.7% (OR 1.027; 95% CI 1.003, 1.051; P = .025) with a 1 U/ml increase in CA125, and by 10.6% (OR 1.106; 95% CI 1.002, 1.220; P = .045) with a 1 unit increase in PNR. It was suggested that together impacts of elevated plasma D-dimer, CA125, CEA levels, and a greater PNR may lead to hypercoagulability and to trigger the development of cancer-related CVST. |
format | Online Article Text |
id | pubmed-6531122 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-65311222019-06-25 A clinical research on the potential pathogenesis of somatic cancer related cerebral venous sinus thrombosis Xian, Ziqiang Chen, Yicong Chen, Li Lu, Qiuhong Huang, Gelun Qin, Qixiong Zeng, Jinsheng Liang, Zhijian Medicine (Baltimore) Research Article To investigate the pathogenesis of somatic solid cancer-related cerebral venous sinus thrombosis (CVST). A total of 174 patients with CVST were recruited from the hospital between January 2006 and December 2017 and divided into two groups: (1) somatic cancer-related CVST group, defined as active somatic solid cancer patients with acute CVST; (2) cancer group (CG), defined as active somatic solid cancer patients without CVST. The cancer group patients were age and gender-matched somatic cancer-related CVST group patients. In addition, the types and amount distribution of cancer in cancer group were also matched with somatic cancer-related CVST group patients. Compared to cancer group patients, somatic cancer-related CVST group patients had more intracranial metastasis, a higher platelet count, higher plasma D-dimer, carcinoembryonic antigen (CEA) and cancer antigen (CA) 125 levels, a greater platelet to lymphocyte ratio (PLR), and a greater platelet to neutrophil ratio (PNR). The risk for CVST in somatic cancer-related CVST group patients increased independently by 0.7% (odds ratio [OR] 1.007; 95% confidence interval [CI] 1.000, 1.015; P = .047) with a 1 ng/ml increase in D-dimer levels, by 4.6% (OR 1.046; 95% CI 1.011, 1.083; P = .010) with a 1 U/ml increase in CEA, by 2.7% (OR 1.027; 95% CI 1.003, 1.051; P = .025) with a 1 U/ml increase in CA125, and by 10.6% (OR 1.106; 95% CI 1.002, 1.220; P = .045) with a 1 unit increase in PNR. It was suggested that together impacts of elevated plasma D-dimer, CA125, CEA levels, and a greater PNR may lead to hypercoagulability and to trigger the development of cancer-related CVST. Wolters Kluwer Health 2019-05-13 /pmc/articles/PMC6531122/ /pubmed/31083150 http://dx.doi.org/10.1097/MD.0000000000015134 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | Research Article Xian, Ziqiang Chen, Yicong Chen, Li Lu, Qiuhong Huang, Gelun Qin, Qixiong Zeng, Jinsheng Liang, Zhijian A clinical research on the potential pathogenesis of somatic cancer related cerebral venous sinus thrombosis |
title | A clinical research on the potential pathogenesis of somatic cancer related cerebral venous sinus thrombosis |
title_full | A clinical research on the potential pathogenesis of somatic cancer related cerebral venous sinus thrombosis |
title_fullStr | A clinical research on the potential pathogenesis of somatic cancer related cerebral venous sinus thrombosis |
title_full_unstemmed | A clinical research on the potential pathogenesis of somatic cancer related cerebral venous sinus thrombosis |
title_short | A clinical research on the potential pathogenesis of somatic cancer related cerebral venous sinus thrombosis |
title_sort | clinical research on the potential pathogenesis of somatic cancer related cerebral venous sinus thrombosis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531122/ https://www.ncbi.nlm.nih.gov/pubmed/31083150 http://dx.doi.org/10.1097/MD.0000000000015134 |
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