Cargando…
The prognostic values of insulin-like growth factor binding protein in breast cancer
Insulin-like growth factor binding proteins (IGFBPs) are a family of proteins binding to insulin-like growth factors, generally consisting 6 high-affinity IGFBPs, namely IGFBP1 through IGFBP6. IGFBP family members have been indicated to be involved in the development and progression of tumors and ma...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531130/ https://www.ncbi.nlm.nih.gov/pubmed/31083221 http://dx.doi.org/10.1097/MD.0000000000015561 |
_version_ | 1783420763921973248 |
---|---|
author | Wang, Jiao Luo, Xin-Xin Tang, Yun-Liang Xu, Ji-Xion Zeng, Zhen-Guo |
author_facet | Wang, Jiao Luo, Xin-Xin Tang, Yun-Liang Xu, Ji-Xion Zeng, Zhen-Guo |
author_sort | Wang, Jiao |
collection | PubMed |
description | Insulin-like growth factor binding proteins (IGFBPs) are a family of proteins binding to insulin-like growth factors, generally consisting 6 high-affinity IGFBPs, namely IGFBP1 through IGFBP6. IGFBP family members have been indicated to be involved in the development and progression of tumors and may be useful prognostic biomarkers in various malignancies. However, the prognostic role of individual IGFBPs, especially at the mRNA level in breast cancer patients remains elusive. We accessed the prognostic roles of IGFBPs family (IGFBP1-6) in breast cancer through the “Kaplan–Meier plotter” online database and OncoLnc database. Our results showed that the high expression of IGFBP1 mRNA was associated with favorable relapsed free survival (RFS) in all breast cancer patients. The high expression of IGFBP2 mRNA was associated with favorable overall survival (OS) and RFS in all breast cancer patients. The high expression of IGFBP3 mRNA was significantly correlated to worsen RFS in all breast cancer patients. The high expression of IGFBP4 mRNA was associated with favorable OS, RFS, distant metastasis-free survival, and post-progression survival in all breast cancer patients. Our results indicated that expression of IGFBPs mRNA may have prognostic values in breast cancer patients, and have a benefit for developing tools to predict the prognosis more accurately. |
format | Online Article Text |
id | pubmed-6531130 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-65311302019-06-25 The prognostic values of insulin-like growth factor binding protein in breast cancer Wang, Jiao Luo, Xin-Xin Tang, Yun-Liang Xu, Ji-Xion Zeng, Zhen-Guo Medicine (Baltimore) Research Article Insulin-like growth factor binding proteins (IGFBPs) are a family of proteins binding to insulin-like growth factors, generally consisting 6 high-affinity IGFBPs, namely IGFBP1 through IGFBP6. IGFBP family members have been indicated to be involved in the development and progression of tumors and may be useful prognostic biomarkers in various malignancies. However, the prognostic role of individual IGFBPs, especially at the mRNA level in breast cancer patients remains elusive. We accessed the prognostic roles of IGFBPs family (IGFBP1-6) in breast cancer through the “Kaplan–Meier plotter” online database and OncoLnc database. Our results showed that the high expression of IGFBP1 mRNA was associated with favorable relapsed free survival (RFS) in all breast cancer patients. The high expression of IGFBP2 mRNA was associated with favorable overall survival (OS) and RFS in all breast cancer patients. The high expression of IGFBP3 mRNA was significantly correlated to worsen RFS in all breast cancer patients. The high expression of IGFBP4 mRNA was associated with favorable OS, RFS, distant metastasis-free survival, and post-progression survival in all breast cancer patients. Our results indicated that expression of IGFBPs mRNA may have prognostic values in breast cancer patients, and have a benefit for developing tools to predict the prognosis more accurately. Wolters Kluwer Health 2019-05-13 /pmc/articles/PMC6531130/ /pubmed/31083221 http://dx.doi.org/10.1097/MD.0000000000015561 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | Research Article Wang, Jiao Luo, Xin-Xin Tang, Yun-Liang Xu, Ji-Xion Zeng, Zhen-Guo The prognostic values of insulin-like growth factor binding protein in breast cancer |
title | The prognostic values of insulin-like growth factor binding protein in breast cancer |
title_full | The prognostic values of insulin-like growth factor binding protein in breast cancer |
title_fullStr | The prognostic values of insulin-like growth factor binding protein in breast cancer |
title_full_unstemmed | The prognostic values of insulin-like growth factor binding protein in breast cancer |
title_short | The prognostic values of insulin-like growth factor binding protein in breast cancer |
title_sort | prognostic values of insulin-like growth factor binding protein in breast cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531130/ https://www.ncbi.nlm.nih.gov/pubmed/31083221 http://dx.doi.org/10.1097/MD.0000000000015561 |
work_keys_str_mv | AT wangjiao theprognosticvaluesofinsulinlikegrowthfactorbindingproteininbreastcancer AT luoxinxin theprognosticvaluesofinsulinlikegrowthfactorbindingproteininbreastcancer AT tangyunliang theprognosticvaluesofinsulinlikegrowthfactorbindingproteininbreastcancer AT xujixion theprognosticvaluesofinsulinlikegrowthfactorbindingproteininbreastcancer AT zengzhenguo theprognosticvaluesofinsulinlikegrowthfactorbindingproteininbreastcancer AT wangjiao prognosticvaluesofinsulinlikegrowthfactorbindingproteininbreastcancer AT luoxinxin prognosticvaluesofinsulinlikegrowthfactorbindingproteininbreastcancer AT tangyunliang prognosticvaluesofinsulinlikegrowthfactorbindingproteininbreastcancer AT xujixion prognosticvaluesofinsulinlikegrowthfactorbindingproteininbreastcancer AT zengzhenguo prognosticvaluesofinsulinlikegrowthfactorbindingproteininbreastcancer |