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High OGT activity is essential for MYC-driven proliferation of prostate cancer cells

O-GlcNAc transferase (OGT) is overexpressed in aggressive prostate cancer. OGT modifies intra-cellular proteins via single sugar conjugation (O-GlcNAcylation) to alter their activity. We recently discovered the first fast-acting OGT inhibitor OSMI-2. Here, we probe the stability and function of the...

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Detalles Bibliográficos
Autores principales:	Itkonen, Harri M, Urbanucci, Alfonso, Martin, Sara ES, Khan, Aziz, Mathelier, Anthony, Thiede, Bernd, Walker, Suzanne, Mills, Ian G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531294/ https://www.ncbi.nlm.nih.gov/pubmed/31149037 http://dx.doi.org/10.7150/thno.30834

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