Progerin accumulation in nucleus pulposus cells impairs mitochondrial function and induces intervertebral disc degeneration and therapeutic effects of sulforaphane

Progerin, a truncated unprocessed lamin A protein, causes tissue aging and degeneration. In this study we explored the role of progerin in the pathogenesis of intervertebral disc degeneration (IDD). We also examined the effect of sulforaphane (SFN) on progerin accumulation and mitochondrial dysfunct...

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Detalles Bibliográficos
Autores principales: Xu, Xiaolong, Wang, Di, Zheng, Chao, Gao, Bo, Fan, Jing, Cheng, Pengzhen, Liu, Baohua, Yang, Liu, Luo, Zhuojing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531300/
https://www.ncbi.nlm.nih.gov/pubmed/31149042
http://dx.doi.org/10.7150/thno.30658

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531300/
https://www.ncbi.nlm.nih.gov/pubmed/31149042
http://dx.doi.org/10.7150/thno.30658

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