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Adaptive plasticity of IL-10(+) and IL-35(+) T(reg) cells cooperatively promotes tumor T cell exhaustion

Regulatory T cells (T(reg) cells) maintain host self-tolerance but are a major barrier to effective cancer immunotherapy. T(reg) cells subvert beneficial anti-tumor immunity by modulating inhibitory receptor expression on tumor-infiltrating lymphocytes (TILs); however, the underlying mediators and m...

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Detalles Bibliográficos
Autores principales:	Sawant, Deepali V., Yano, Hiroshi, Chikina, Maria, Zhang, Qianxia, Liao, Mengting, Liu, Chang, Callahan, Derrick J, Sun, Zhe, Sun, Tao, Tabib, Tracy, Pennathur, Arjun, Corry, David B., Luketich, James D., Lafyatis, Robert, Chen, Wei, Poholek, Amanda C., Bruno, Tullia C., Workman, Creg J., Vignali, Dario A.A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531353/ https://www.ncbi.nlm.nih.gov/pubmed/30936494 http://dx.doi.org/10.1038/s41590-019-0346-9

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