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Dynamic Role of the G Protein in Stabilizing the Active State of the Adenosine A(2A) Receptor
Agonist binding in the extracellular region of the G protein-coupled adenosine A2A receptor increases its affinity to the G proteins in the intracellular region, and vice versa. The structural basis for this effect is not evident from the crystal structures of A(2A)R in various conformational states...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531377/ https://www.ncbi.nlm.nih.gov/pubmed/30713025 http://dx.doi.org/10.1016/j.str.2018.12.007 |