A Translational Quantitative Systems Pharmacology Model for CD3 Bispecific Molecules: Application to Quantify T Cell-Mediated Tumor Cell Killing by P-Cadherin LP DART(®)

CD3 bispecific antibody constructs recruit cytolytic T cells to kill tumor cells, offering a potent approach to treat cancer. T cell activation is driven by the formation of a trimolecular complex (trimer) between drugs, T cells, and tumor cells, mimicking an immune synapse. A translational quantita...

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Detalles Bibliográficos
Autores principales: Betts, Alison, Haddish-Berhane, Nahor, Shah, Dhaval K., van der Graaf, Piet H., Barletta, Frank, King, Lindsay, Clark, Tracey, Kamperschroer, Cris, Root, Adam, Hooper, Andrea, Chen, Xiaoying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531394/
https://www.ncbi.nlm.nih.gov/pubmed/31119428
http://dx.doi.org/10.1208/s12248-019-0332-z

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