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Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains

The cytoplasmic accumulation of the nuclear TAR DNA-binding protein 43 (TDP-43) is a pathologic hallmark in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and other neurological disorders. However, most transgenic TDP-43 rodent models show predominant nuclear distribution of TDP-4...

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Detalles Bibliográficos
Autores principales:	Yin, Peng, Guo, Xiangyu, Yang, Weili, Yan, Sen, Yang, Su, Zhao, Ting, Sun, Qiang, Liu, Yunbo, Li, Shihua, Li, Xiao-Jiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2019
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531422/ https://www.ncbi.nlm.nih.gov/pubmed/30810811 http://dx.doi.org/10.1007/s00401-019-01979-0

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