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Utility of albumin to creatinine ratio in screening for microalbuminuria among newly diagnosed diabetic patients in Uganda: a cross sectional study

BACKGROUND: The aim of this study was to determine the prevalence and factors associated with microalbuminuria among newly diagnosed diabetic patients in Mulago National Referral Hospital, Uganda. METHODS: In this cross-sectional study conducted between June 2014 and January 2015, we collected infor...

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Autores principales: Muddu, Martin, Mutebi, Edrisa, Ssinabulya, Isaac, Kizito, Samuel, Mulindwa, Frank, Kiiza, Charles Mondo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Makerere Medical School 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531967/
https://www.ncbi.nlm.nih.gov/pubmed/31148990
http://dx.doi.org/10.4314/ahs.v19i1.36
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author Muddu, Martin
Mutebi, Edrisa
Ssinabulya, Isaac
Kizito, Samuel
Mulindwa, Frank
Kiiza, Charles Mondo
author_facet Muddu, Martin
Mutebi, Edrisa
Ssinabulya, Isaac
Kizito, Samuel
Mulindwa, Frank
Kiiza, Charles Mondo
author_sort Muddu, Martin
collection PubMed
description BACKGROUND: The aim of this study was to determine the prevalence and factors associated with microalbuminuria among newly diagnosed diabetic patients in Mulago National Referral Hospital, Uganda. METHODS: In this cross-sectional study conducted between June 2014 and January 2015, we collected information on patients' socio-demographics, biophysical profile, blood pressure, biochemical testing and echocardiographic findings using a pre-tested questionnaire. Bivariate and multivariate logistic regression analyses were used to investigate the association of several factors with microalbuminuria. RESULTS: Of the 175 patients recruited, males were 90(51.4%) and the mean age was 46±15 years. Majority of patients had type 2 DM 140 (80.0%) and the rest had type 1 DM 35 (20.0%). Mean glycated hemoglobin (HbA1C) was 13.9±5.3%. Mean duration of diabetes was 2 months. Prevalence of microalbuminuria was 47.4 % (95% CI: 40.0%-54.9%) overall. Pregnancy was associated with microalbuminuria (OR7.74[95%CI.1.01–76.47] P=0.050) while mild and moderate physical activity at work were inversely associated with microalbuminuria respectively (OR0.08[95%CI0.01–0.95] P=0.046) and (OR0.07[95%CI0.01–0.77] P=0.030). CONCLUSION: Prevalence of microalbuminuria was high in this group. Physical activity at work may be protective against microalbuminuria and this calls for longitudinal studies. Early detection and management of microalbuminuria in diabetics may slow progression to overt diabetic nephropathy (DN).
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spelling pubmed-65319672019-05-30 Utility of albumin to creatinine ratio in screening for microalbuminuria among newly diagnosed diabetic patients in Uganda: a cross sectional study Muddu, Martin Mutebi, Edrisa Ssinabulya, Isaac Kizito, Samuel Mulindwa, Frank Kiiza, Charles Mondo Afr Health Sci Articles BACKGROUND: The aim of this study was to determine the prevalence and factors associated with microalbuminuria among newly diagnosed diabetic patients in Mulago National Referral Hospital, Uganda. METHODS: In this cross-sectional study conducted between June 2014 and January 2015, we collected information on patients' socio-demographics, biophysical profile, blood pressure, biochemical testing and echocardiographic findings using a pre-tested questionnaire. Bivariate and multivariate logistic regression analyses were used to investigate the association of several factors with microalbuminuria. RESULTS: Of the 175 patients recruited, males were 90(51.4%) and the mean age was 46±15 years. Majority of patients had type 2 DM 140 (80.0%) and the rest had type 1 DM 35 (20.0%). Mean glycated hemoglobin (HbA1C) was 13.9±5.3%. Mean duration of diabetes was 2 months. Prevalence of microalbuminuria was 47.4 % (95% CI: 40.0%-54.9%) overall. Pregnancy was associated with microalbuminuria (OR7.74[95%CI.1.01–76.47] P=0.050) while mild and moderate physical activity at work were inversely associated with microalbuminuria respectively (OR0.08[95%CI0.01–0.95] P=0.046) and (OR0.07[95%CI0.01–0.77] P=0.030). CONCLUSION: Prevalence of microalbuminuria was high in this group. Physical activity at work may be protective against microalbuminuria and this calls for longitudinal studies. Early detection and management of microalbuminuria in diabetics may slow progression to overt diabetic nephropathy (DN). Makerere Medical School 2019-03 /pmc/articles/PMC6531967/ /pubmed/31148990 http://dx.doi.org/10.4314/ahs.v19i1.36 Text en © 2019 Muddu et al. Licensee African Health Sciences. This is an Open Access article distributed under the terms of the Creative commons Attribution License (https://creativecommons.org/licenses/BY/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Muddu, Martin
Mutebi, Edrisa
Ssinabulya, Isaac
Kizito, Samuel
Mulindwa, Frank
Kiiza, Charles Mondo
Utility of albumin to creatinine ratio in screening for microalbuminuria among newly diagnosed diabetic patients in Uganda: a cross sectional study
title Utility of albumin to creatinine ratio in screening for microalbuminuria among newly diagnosed diabetic patients in Uganda: a cross sectional study
title_full Utility of albumin to creatinine ratio in screening for microalbuminuria among newly diagnosed diabetic patients in Uganda: a cross sectional study
title_fullStr Utility of albumin to creatinine ratio in screening for microalbuminuria among newly diagnosed diabetic patients in Uganda: a cross sectional study
title_full_unstemmed Utility of albumin to creatinine ratio in screening for microalbuminuria among newly diagnosed diabetic patients in Uganda: a cross sectional study
title_short Utility of albumin to creatinine ratio in screening for microalbuminuria among newly diagnosed diabetic patients in Uganda: a cross sectional study
title_sort utility of albumin to creatinine ratio in screening for microalbuminuria among newly diagnosed diabetic patients in uganda: a cross sectional study
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531967/
https://www.ncbi.nlm.nih.gov/pubmed/31148990
http://dx.doi.org/10.4314/ahs.v19i1.36
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