By Binding CD80 and CD86, the Vaccinia Virus M2 Protein Blocks Their Interactions with both CD28 and CTLA4 and Potentiates CD80 Binding to PD-L1

In this article we report that the M2 protein encoded by the vaccinia virus is secreted as a homo-oligomer by infected cells and binds two central costimulation molecules, CD80 (B7-1) and CD86 (B7-2). These interactions block the ligation of the two B7 proteins to both soluble CD28 and soluble cytot...

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Detalles Bibliográficos
Autores principales: Kleinpeter, Patricia, Remy-Ziller, Christelle, Winter, Eline, Gantzer, Murielle, Nourtier, Virginie, Kempf, Juliette, Hortelano, Julie, Schmitt, Doris, Schultz, Huguette, Geist, Michel, Brua, Catherine, Hoffmann, Chantal, Schlesinger, Yasmin, Villeval, Dominique, Thioudellet, Christine, Erbs, Philippe, Foloppe, Johann, Silvestre, Nathalie, Fend, Laetitia, Quemeneur, Eric, Marchand, Jean-Baptiste
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Virus-Cell Interactions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532080/
https://www.ncbi.nlm.nih.gov/pubmed/30918073
http://dx.doi.org/10.1128/JVI.00207-19

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