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Two Coselected Distal Mutations in HIV-1 Reverse Transcriptase (RT) Alter Susceptibility to Nonnucleoside RT Inhibitors and Nucleoside Analogs

Two mutations, G112D and M230I, were selected in the reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) by a novel nonnucleoside reverse transcriptase inhibitor (NNRTI). G112D is located near the HIV-1 polymerase active site; M230I is located near the hydrophobic region where...

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Detalles Bibliográficos
Autores principales:	Boyer, Paul L., Melody, Kevin, Smith, Steven J., Dunn, Linda L., Kline, Chris, Fischer, Douglas K., Dwivedi, Richa, Clark, Pat, Hughes, Stephen H., Ambrose, Zandrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2019
Materias:	Vaccines and Antiviral Agents
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532099/ https://www.ncbi.nlm.nih.gov/pubmed/30894467 http://dx.doi.org/10.1128/JVI.00224-19

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