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The ionophore antibiotic gramicidin A inhibits pancreatic cancer stem cells associated with CD47 down-regulation

BACKGROUND: Pancreatic cancer stem cells (CSCs), a special population of cells, renew themselves infinitely and resist to various treatment. Gramicidin A (GrA), an ionophore antibiotic derived from microorganism, can form channels across the cell membrane and disrupt cellular ionic homeostasis, lead...

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Detalles Bibliográficos
Autores principales:	Wang, Rui-Qi, Geng, Jing, Sheng, Wei-Jin, Liu, Xiu-Jun, Jiang, Min, Zhen, Yong-Su
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532126/ https://www.ncbi.nlm.nih.gov/pubmed/31139022 http://dx.doi.org/10.1186/s12935-019-0862-6

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