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A low-molecular-weight compound exerts anticancer activity against breast and lung cancers by disrupting EGFR/Eps8 complex formation

BACKGROUND: Epidermal growth factor receptor (EGFR) and epidermal growth factor receptor pathway substrate 8 (Eps8) have been widely reported to be expressed in various tumors. Eps8 is an important active kinase substrate of EGFR that directly binds to the juxtamembrane (JXM) domain of EGFR to form...

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Detalles Bibliográficos
Autores principales:	Li, Meifang, Yang, Jilong, Zhang, Lenghe, Tu, Sanfang, Zhou, Xuan, Tan, Ze, Zhou, Weijun, He, Yanjie, Li, Yuhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532146/ https://www.ncbi.nlm.nih.gov/pubmed/31118055 http://dx.doi.org/10.1186/s13046-019-1207-y

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