Joint association of mammographic density adjusted for age and body mass index and polygenic risk score with breast cancer risk

BACKGROUND: Mammographic breast density, adjusted for age and body mass index, and a polygenic risk score (PRS), comprised of common genetic variation, are both strong risk factors for breast cancer and increase discrimination of risk models. Understanding their joint contribution will be important...

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Detalles Bibliográficos
Autores principales: Vachon, Celine M., Scott, Christopher G., Tamimi, Rulla M., Thompson, Deborah J., Fasching, Peter A., Stone, Jennifer, Southey, Melissa C., Winham, Stacey, Lindström, Sara, Lilyquist, Jenna, Giles, Graham G., Milne, Roger L., MacInnis, Robert J., Baglietto, Laura, Li, Jingmei, Czene, Kamila, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Haeberle, Lothar, Eriksson, Mikael, Kraft, Peter, Luben, Robert, Wareham, Nick, Olson, Janet E., Norman, Aaron, Polley, Eric C., Maskarinec, Gertraud, Le Marchand, Loic, Haiman, Christopher A., Hopper, John L., Couch, Fergus J., Easton, Douglas F., Hall, Per, Chatterjee, Nilanjan, Garcia-Closas, Montse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532188/
https://www.ncbi.nlm.nih.gov/pubmed/31118087
http://dx.doi.org/10.1186/s13058-019-1138-8

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