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Glutathione “Redox Homeostasis” and Its Relation to Cardiovascular Disease
More people die from cardiovascular diseases (CVD) than from any other cause. Cardiovascular complications are thought to arise from enhanced levels of free radicals causing impaired “redox homeostasis,” which represents the interplay between oxidative stress (OS) and reductive stress (RS). In this...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532282/ https://www.ncbi.nlm.nih.gov/pubmed/31210841 http://dx.doi.org/10.1155/2019/5028181 |
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author | Bajic, Vladan P. Van Neste, Christophe Obradovic, Milan Zafirovic, Sonja Radak, Djordje Bajic, Vladimir B. Essack, Magbubah Isenovic, Esma R. |
author_facet | Bajic, Vladan P. Van Neste, Christophe Obradovic, Milan Zafirovic, Sonja Radak, Djordje Bajic, Vladimir B. Essack, Magbubah Isenovic, Esma R. |
author_sort | Bajic, Vladan P. |
collection | PubMed |
description | More people die from cardiovascular diseases (CVD) than from any other cause. Cardiovascular complications are thought to arise from enhanced levels of free radicals causing impaired “redox homeostasis,” which represents the interplay between oxidative stress (OS) and reductive stress (RS). In this review, we compile several experimental research findings that show sustained shifts towards OS will alter the homeostatic redox mechanism to cause cardiovascular complications, as well as findings that show a prolonged antioxidant state or RS can similarly lead to such cardiovascular complications. This experimental evidence is specifically focused on the role of glutathione, the most abundant antioxidant in the heart, in a redox homeostatic mechanism that has been shifted towards OS or RS. This may lead to impairment of cellular signaling mechanisms and elevated pools of proteotoxicity associated with cardiac dysfunction. |
format | Online Article Text |
id | pubmed-6532282 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-65322822019-06-17 Glutathione “Redox Homeostasis” and Its Relation to Cardiovascular Disease Bajic, Vladan P. Van Neste, Christophe Obradovic, Milan Zafirovic, Sonja Radak, Djordje Bajic, Vladimir B. Essack, Magbubah Isenovic, Esma R. Oxid Med Cell Longev Review Article More people die from cardiovascular diseases (CVD) than from any other cause. Cardiovascular complications are thought to arise from enhanced levels of free radicals causing impaired “redox homeostasis,” which represents the interplay between oxidative stress (OS) and reductive stress (RS). In this review, we compile several experimental research findings that show sustained shifts towards OS will alter the homeostatic redox mechanism to cause cardiovascular complications, as well as findings that show a prolonged antioxidant state or RS can similarly lead to such cardiovascular complications. This experimental evidence is specifically focused on the role of glutathione, the most abundant antioxidant in the heart, in a redox homeostatic mechanism that has been shifted towards OS or RS. This may lead to impairment of cellular signaling mechanisms and elevated pools of proteotoxicity associated with cardiac dysfunction. Hindawi 2019-05-09 /pmc/articles/PMC6532282/ /pubmed/31210841 http://dx.doi.org/10.1155/2019/5028181 Text en Copyright © 2019 Vladan P. Bajic et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Bajic, Vladan P. Van Neste, Christophe Obradovic, Milan Zafirovic, Sonja Radak, Djordje Bajic, Vladimir B. Essack, Magbubah Isenovic, Esma R. Glutathione “Redox Homeostasis” and Its Relation to Cardiovascular Disease |
title | Glutathione “Redox Homeostasis” and Its Relation to Cardiovascular Disease |
title_full | Glutathione “Redox Homeostasis” and Its Relation to Cardiovascular Disease |
title_fullStr | Glutathione “Redox Homeostasis” and Its Relation to Cardiovascular Disease |
title_full_unstemmed | Glutathione “Redox Homeostasis” and Its Relation to Cardiovascular Disease |
title_short | Glutathione “Redox Homeostasis” and Its Relation to Cardiovascular Disease |
title_sort | glutathione “redox homeostasis” and its relation to cardiovascular disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532282/ https://www.ncbi.nlm.nih.gov/pubmed/31210841 http://dx.doi.org/10.1155/2019/5028181 |
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