Cargando…

Bloom Syndrome Protein Activates AKT and PRAS40 in Prostate Cancer Cells

PURPOSE: Prostate cancer (PC) is a common malignant tumor and a leading cause of cancer-related death in men worldwide. In order to design new therapeutic interventions for PC, an understanding of the molecular events underlying PC tumorigenesis is required. Bloom syndrome protein (BLM) is a RecQ-li...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Kun, Xu, Houqiang, Zhao, Jiafu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532288/ https://www.ncbi.nlm.nih.gov/pubmed/31210839 http://dx.doi.org/10.1155/2019/3685817

Ejemplares similares

PRAS40 signaling in tumor
por: Lv, Dan, et al.
Publicado: (2017)

PRAS40 hyperexpression promotes hepatocarcinogenesis
por: Qi, Zhaolai, et al.
Publicado: (2020)

mTOR/PRAS40 interaction: Hypertrophy or proliferation
por: Völkers, Mirko, et al.
Publicado: (2013)

Effect of PI3K/Akt Signaling Pathway on PRAS40Thr246 Phosphorylation in Gastric Cancer Cells
por: LU, Yizhuo, et al.
Publicado: (2019)

Structural Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40
por: Yang, Haijuan, et al.
Publicado: (2017)

PRAS40 Is an Integral Regulatory Component of Erythropoietin mTOR Signaling and Cytoprotection
por: Chong, Zhao Zhong, et al.
Publicado: (2012)

Prognostic role of phospho-PRAS40 (Thr246) expression in gastric cancer
por: Lu, Yi-Zhuo, et al.
Publicado: (2013)

TIFA promotes colorectal cancer cell proliferation in an RSK‐ and PRAS40‐dependent manner
por: Shen, Wenzhi, et al.
Publicado: (2022)

PRAS40 and PRR5-Like Protein Are New mTOR Interactors that Regulate Apoptosis
por: Thedieck, Kathrin, et al.
Publicado: (2007)

Automated quantitative multiplex immunofluorescence in situ imaging identifies phospho-S6 and phospho-PRAS40 as predictive protein biomarkers for prostate cancer lethality
por: Shipitsin, Michail, et al.
Publicado: (2014)

PRAS40 promotes NF-κB transcriptional activity through association with p65
por: Zhu, G, et al.
Publicado: (2017)

Contribution of Elevated Glucose and Oxidized LDL to Macrophage Inflammation: A Role for PRAS40/Akt-Dependent Shedding of Soluble CD14
por: Sanjurjo, Lucía, et al.
Publicado: (2023)

Phosphorylation of PRAS40 contributes to the activation of the PI3K/AKT/mTOR signaling pathway and the inhibition of autophagy following status epilepticus in rats
por: Lin, Junyi, et al.
Publicado: (2020)

Trimedazidine alleviates pulmonary artery banding-induced acute right heart dysfunction and activates PRAS40 in rats
por: Cao, Yunshan, et al.
Publicado: (2017)

PRAS40 prevents development of diabetic cardiomyopathy and improves hepatic insulin sensitivity in obesity
por: Völkers, Mirko, et al.
Publicado: (2014)

Corrigendum to ‘PRAS40 hyperexpression promotes hepatocarcinogenesis’ [EBioMedicine 51 (2020) 102,604]
por: Qi, Zhaolai, et al.
Publicado: (2020)

PGK1 represses autophagy-mediated cell death to promote the proliferation of liver cancer cells by phosphorylating PRAS40
por: Zhang, Tianhua, et al.
Publicado: (2022)

The Molecular Landscape and Biological Alterations Induced by PRAS40-Knockout in Head and Neck Squamous Cell Carcinoma
por: Chen, Gang, et al.
Publicado: (2021)

AKT inhibition overcomes rapamycin resistance by enhancing the repressive function of PRAS40 on mTORC1/4E-BP1 axis
por: Mi, Wenting, et al.
Publicado: (2015)

High PRAS40 mRNA expression and its role in prognosis of clear cell renal cell carcinoma
por: Zhou, Jintuo, et al.
Publicado: (2020)

miR-29b-3p inhibits 22Rv1 prostate cancer cell proliferation through the YWHAE/BCL-2 regulatory axis
por: Zhao, Jiafu, et al.
Publicado: (2022)

Phospho-PRAS40(Thr246) predicts trastuzumab response in patients with HER2-positive metastatic breast cancer
por: YUAN, KAI, et al.
Publicado: (2015)

Interaction Between CD34(+) Fibrocytes and Airway Smooth Muscle Promotes IL-8 Production and Akt/PRAS40/mTOR Signaling in Asthma
por: Lin, Ting-Yu, et al.
Publicado: (2022)

P2X7 Integrates PI3K/AKT and AMPK-PRAS40-mTOR Signaling Pathways to Mediate Tumor Cell Death
por: Bian, Shu, et al.
Publicado: (2013)

MELK is Upregulated in Advanced Clear Cell Renal Cell Carcinoma and Promotes Disease Progression by Phosphorylating PRAS40
por: Zhang, Han, et al.
Publicado: (2019)

TGFβ signaling-induced miRNA participates in autophagic regulation by targeting PRAS40 in mesenchymal subtype of glioblastoma
por: Xie, Yingbin, et al.
Publicado: (2020)

Nuclear PRAS40 couples the Akt/mTORC1 signaling axis to the RPL11-HDM2-p53 nucleolar stress response pathway
por: Havel, Jonathan J., et al.
Publicado: (2014)

p53 Inhibition Protects against Neuronal Ischemia/Reperfusion Injury by the p53/PRAS40/mTOR Pathway
por: Zhao, Jianlan, et al.
Publicado: (2021)

miR-31-5p Regulates 14-3-3 ɛ to Inhibit Prostate Cancer 22RV1 Cell Survival and Proliferation via PI3K/AKT/Bcl-2 Signaling Pathway
por: Zhao, Jiafu, et al.
Publicado: (2020)

PRAS40 suppresses atherogenesis through inhibition of mTORC1-dependent pro-inflammatory signaling in endothelial cells
por: Zhang, Kevin Sun, et al.
Publicado: (2019)

Calcineurin Inhibitor-Induced and Ras-Mediated Overexpression of VEGF in Renal Cancer Cells Involves mTOR through the Regulation of PRAS40
por: Basu, Aninda, et al.
Publicado: (2011)

Discovery of a Novel Bloom’s Syndrome Protein (BLM) Inhibitor Suppressing Growth and Metastasis of Prostate Cancer
por: Ma, Xiao-Yan, et al.
Publicado: (2022)

Aescin Protects Neuron from Ischemia-Reperfusion Injury via Regulating the PRAS40/mTOR Signaling Pathway
por: Gao, Xinjie, et al.
Publicado: (2020)

Pyrroline-5-Carboxylate Reductase 1: a novel target for sensitizing multiple myeloma cells to bortezomib by inhibition of PRAS40-mediated protein synthesis
por: Oudaert, Inge, et al.
Publicado: (2022)

PTEN inhibitor VO-OHpic suppresses TSC2(-)(/)(-) MEFs proliferation by excessively inhibiting autophagy via the PTEN/PRAS40 pathway
por: Wang, Wenda, et al.
Publicado: (2020)

PRAS: Predicting functional targets of RNA binding proteins based on CLIP-seq peaks
por: Lin, Jianan, et al.
Publicado: (2019)

Alga-PrAS (Algal Protein Annotation Suite): A Database of Comprehensive Annotation in Algal Proteomes
por: Kurotani, Atsushi, et al.
Publicado: (2017)

Pancreatic cancer in bloom syndrome
por: Tzfoni, Itai, et al.
Publicado: (2019)

The cytogenetics of Bloom’s syndrome
por: Singh, Ashish, et al.
Publicado: (2010)

Immunodeficiency in Bloom’s Syndrome
por: Schoenaker, Michiel H. D., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_7b79vgmeccige6n59frl6biv94