CTLA4 Message Reflects Pathway Disruption in Monogenic Disorders and Under Therapeutic Blockade

CTLA-4 is essential for immune tolerance. Heterozygous CTLA4 mutations cause immune dysregulation evident in defective regulatory T cells with low levels of CTLA-4 expression. Biallelic mutations in LRBA also result in immune dysregulation with low levels of CTLA-4 and clinical presentation indistin...

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Detalles Bibliográficos
Autores principales: Garcia-Perez, Josselyn E., Baxter, Ryan M., Kong, Daniel S., Tobin, Richard, McCarter, Martin, Routes, John M., Verbsky, James, Jordan, Michael B., Dutmer, Cullen M., Hsieh, Elena W. Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532297/
https://www.ncbi.nlm.nih.gov/pubmed/31156616
http://dx.doi.org/10.3389/fimmu.2019.00998

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