A single‐center, open‐label positron emission tomography study to evaluate brivaracetam and levetiracetam synaptic vesicle glycoprotein 2A binding in healthy volunteers

OBJECTIVE: Brivaracetam (BRV) and levetiracetam (LEV) are antiepileptic drugs that bind synaptic vesicle glycoprotein 2A (SV2A). In vitro and in vivo animal studies suggest faster brain penetration and SV2A occupancy (SO) after dosing with BRV than LEV. We evaluated human brain penetration and SO ti...

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Detalles Bibliográficos
Autores principales: Finnema, Sjoerd J., Rossano, Samantha, Naganawa, Mika, Henry, Shannan, Gao, Hong, Pracitto, Richard, Maguire, Ralph P., Mercier, Joël, Kervyn, Sophie, Nicolas, Jean‐Marie, Klitgaard, Henrik, DeBruyn, Steven, Otoul, Christian, Martin, Paul, Muglia, Pierandrea, Matuskey, David, Nabulsi, Nabeel B., Huang, Yiyun, Kaminski, Rafal M., Hannestad, Jonas, Stockis, Armel, Carson, Richard E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Full‐length Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532410/
https://www.ncbi.nlm.nih.gov/pubmed/30924924
http://dx.doi.org/10.1111/epi.14701

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