Genetic Alterations Detected in Cell-Free DNA Are Associated With Enzalutamide and Abiraterone Resistance in Castration-Resistant Prostate Cancer

PURPOSE: Androgen receptor (AR) gene alterations, including ligand-binding domain mutations and copy number (CN) gain, have yet to be fully established as predictive markers of resistance to enzalutamide and abiraterone in men with metastatic castration-resistant prostate cancer (mCRPC). The goal of...

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Detalles Bibliográficos
Autores principales: Torquato, Samantha, Pallavajjala, Aparna, Goldstein, Alexa, Valda Toro, Patricia, Silberstein, John L., Lee, Justin, Nakazawa, Mary, Waters, Ian, Chu, David, Shinn, Daniel, Groginski, Taylor, Hughes, Robert M., Simons, Brian W., Khan, Hamda, Feng, Zhaoyong, Carducci, Michael A., Paller, Channing J., Denmeade, Samuel R., Kressel, Bruce, Eisenberger, Mario A., Antonarakis, Emmanuel S., Trock, Bruce J., Park, Ben H., Hurley, Paula J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Clinical Oncology 2019
Materias:
Original Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532665/
https://www.ncbi.nlm.nih.gov/pubmed/31131348
http://dx.doi.org/10.1200/PO.18.00227

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