A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis

Infections of humans and livestock with African trypanosomes are treated with drugs introduced decades ago that are not always fully effective and often have severe side effects. Here, the trypanosome haptoglobin-haemoglobin receptor (HpHbR) has been exploited as a route of uptake for an antibody-dr...

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Detalles Bibliográficos
Autores principales: MacGregor, Paula, Gonzalez-Munoz, Andrea L., Jobe, Fatoumatta, Taylor, Martin C., Rust, Steven, Sandercock, Alan M., Macleod, Olivia J. S., Van Bocxlaer, Katrien, Francisco, Amanda F., D’Hooge, Francois, Tiberghien, Arnaud, Barry, Conor S., Howard, Philip, Higgins, Matthew K., Vaughan, Tristan J., Minter, Ralph, Carrington, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532856/
https://www.ncbi.nlm.nih.gov/pubmed/31120889
http://dx.doi.org/10.1371/journal.pntd.0007373

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