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Identification of immune and metabolic predictors of severe hand-foot-mouth disease

Hand, foot and mouth disease (HFMD) is an infectious disease that affects mostly children. The children with HFMD also have other immune and metabolic disorders. However, the association of these disorders with the severity of HFMD has not yet been determined. In this study, we used a case-control s...

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Autores principales: Qin, Luwei, Dang, Dejian, Wang, Xinhong, Zhang, Rongguang, Feng, Huifen, Ren, Jingchao, Chen, Shuaiyin, Zhou, Guangyuan, Huang, Ping, Wang, Bin, Xi, Yuanlin, Wu, Weidong, Jin, Yuefei, Duan, Guangcai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532886/
https://www.ncbi.nlm.nih.gov/pubmed/31120941
http://dx.doi.org/10.1371/journal.pone.0216993
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author Qin, Luwei
Dang, Dejian
Wang, Xinhong
Zhang, Rongguang
Feng, Huifen
Ren, Jingchao
Chen, Shuaiyin
Zhou, Guangyuan
Huang, Ping
Wang, Bin
Xi, Yuanlin
Wu, Weidong
Jin, Yuefei
Duan, Guangcai
author_facet Qin, Luwei
Dang, Dejian
Wang, Xinhong
Zhang, Rongguang
Feng, Huifen
Ren, Jingchao
Chen, Shuaiyin
Zhou, Guangyuan
Huang, Ping
Wang, Bin
Xi, Yuanlin
Wu, Weidong
Jin, Yuefei
Duan, Guangcai
author_sort Qin, Luwei
collection PubMed
description Hand, foot and mouth disease (HFMD) is an infectious disease that affects mostly children. The children with HFMD also have other immune and metabolic disorders. However, the association of these disorders with the severity of HFMD has not yet been determined. In this study, we used a case-control study design to examine the correlation of immune and metabolic disorders with HFMD development in children. 406 mild and severe patients were recruited and divided into different subgroups based on the number of days from the initial onset time to hospitalization (1, 2, 3, 4, and ≥5 days). Logistic regression model was used to define the predictors of severe HFMD. We found that the patients from rural area (OR = 1.76, 95% CI [1.19~2.63], P = 0.005) or with body temperature of >39°C (OR = 2.14, 95% CI [1.12~4.12], P = 0.022) exhibited higher risk for severe symptoms. In addition, the risk increased with the rise of body temperature by using a Chis-quare trend test (P = 0.01). We also found that a decreased number of eosinophils was an predictor of severe HFMD at 1, 2, 3,and 4 days post infection (dpi). Decreased levels of Na(+), Cl(-), and creatine kinase were also predictors at 1 and ≥5 dpi. On the other hand, elevated level of globulin was a predictor for severe HFMD at 4 dpi and ≥5 dpi, and the increased number of neutrophils or increased level of alkaline phosphatase posed risk for severe HFMD at 3 and ≥5 dpi. Our results suggested that rural living, hyperpyrexia, changes in the immune system that include the numbers of eosinophils and neutrophils and the levels of IgG and globulin, and metabolic alterations, such as the levels of alkaline phosphatase, Na(+), Cl(-), and creatine kinase in peripheral blood are predictors of severe HFMD.
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spelling pubmed-65328862019-06-05 Identification of immune and metabolic predictors of severe hand-foot-mouth disease Qin, Luwei Dang, Dejian Wang, Xinhong Zhang, Rongguang Feng, Huifen Ren, Jingchao Chen, Shuaiyin Zhou, Guangyuan Huang, Ping Wang, Bin Xi, Yuanlin Wu, Weidong Jin, Yuefei Duan, Guangcai PLoS One Research Article Hand, foot and mouth disease (HFMD) is an infectious disease that affects mostly children. The children with HFMD also have other immune and metabolic disorders. However, the association of these disorders with the severity of HFMD has not yet been determined. In this study, we used a case-control study design to examine the correlation of immune and metabolic disorders with HFMD development in children. 406 mild and severe patients were recruited and divided into different subgroups based on the number of days from the initial onset time to hospitalization (1, 2, 3, 4, and ≥5 days). Logistic regression model was used to define the predictors of severe HFMD. We found that the patients from rural area (OR = 1.76, 95% CI [1.19~2.63], P = 0.005) or with body temperature of >39°C (OR = 2.14, 95% CI [1.12~4.12], P = 0.022) exhibited higher risk for severe symptoms. In addition, the risk increased with the rise of body temperature by using a Chis-quare trend test (P = 0.01). We also found that a decreased number of eosinophils was an predictor of severe HFMD at 1, 2, 3,and 4 days post infection (dpi). Decreased levels of Na(+), Cl(-), and creatine kinase were also predictors at 1 and ≥5 dpi. On the other hand, elevated level of globulin was a predictor for severe HFMD at 4 dpi and ≥5 dpi, and the increased number of neutrophils or increased level of alkaline phosphatase posed risk for severe HFMD at 3 and ≥5 dpi. Our results suggested that rural living, hyperpyrexia, changes in the immune system that include the numbers of eosinophils and neutrophils and the levels of IgG and globulin, and metabolic alterations, such as the levels of alkaline phosphatase, Na(+), Cl(-), and creatine kinase in peripheral blood are predictors of severe HFMD. Public Library of Science 2019-05-23 /pmc/articles/PMC6532886/ /pubmed/31120941 http://dx.doi.org/10.1371/journal.pone.0216993 Text en © 2019 Qin et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Qin, Luwei
Dang, Dejian
Wang, Xinhong
Zhang, Rongguang
Feng, Huifen
Ren, Jingchao
Chen, Shuaiyin
Zhou, Guangyuan
Huang, Ping
Wang, Bin
Xi, Yuanlin
Wu, Weidong
Jin, Yuefei
Duan, Guangcai
Identification of immune and metabolic predictors of severe hand-foot-mouth disease
title Identification of immune and metabolic predictors of severe hand-foot-mouth disease
title_full Identification of immune and metabolic predictors of severe hand-foot-mouth disease
title_fullStr Identification of immune and metabolic predictors of severe hand-foot-mouth disease
title_full_unstemmed Identification of immune and metabolic predictors of severe hand-foot-mouth disease
title_short Identification of immune and metabolic predictors of severe hand-foot-mouth disease
title_sort identification of immune and metabolic predictors of severe hand-foot-mouth disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532886/
https://www.ncbi.nlm.nih.gov/pubmed/31120941
http://dx.doi.org/10.1371/journal.pone.0216993
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