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Modified-Release Hydrocortisone: Is It Time to Change Clinical Practice?
The appreciation of the unacceptable outcomes of patients with adrenal insufficiency has brought new developments in glucocorticoid replacement therapy. Efforts have moved beyond simple dose adjustments of the traditional immediate-release hydrocortisone to new formulations of hydrocortisone aimed a...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Endocrine Society
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532954/ https://www.ncbi.nlm.nih.gov/pubmed/31139761 http://dx.doi.org/10.1210/js.2019-00046 |
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author | Stewart, Paul M |
author_facet | Stewart, Paul M |
author_sort | Stewart, Paul M |
collection | PubMed |
description | The appreciation of the unacceptable outcomes of patients with adrenal insufficiency has brought new developments in glucocorticoid replacement therapy. Efforts have moved beyond simple dose adjustments of the traditional immediate-release hydrocortisone to new formulations of hydrocortisone aimed at mimicking the circadian pattern of physiological glucocorticoid release. The present report has briefly summarized the evidence base behind recent studies that have reported benefits using modified-release preparations and set this in context for today’s clinical practice. |
format | Online Article Text |
id | pubmed-6532954 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Endocrine Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-65329542019-05-28 Modified-Release Hydrocortisone: Is It Time to Change Clinical Practice? Stewart, Paul M J Endocr Soc Mini-Review The appreciation of the unacceptable outcomes of patients with adrenal insufficiency has brought new developments in glucocorticoid replacement therapy. Efforts have moved beyond simple dose adjustments of the traditional immediate-release hydrocortisone to new formulations of hydrocortisone aimed at mimicking the circadian pattern of physiological glucocorticoid release. The present report has briefly summarized the evidence base behind recent studies that have reported benefits using modified-release preparations and set this in context for today’s clinical practice. Endocrine Society 2019-04-11 /pmc/articles/PMC6532954/ /pubmed/31139761 http://dx.doi.org/10.1210/js.2019-00046 Text en Copyright © 2019 Endocrine Society https://creativecommons.org/licenses/by-nc-nd/4.0/ This article has been published under the terms of the Creative Commons Attribution Non-Commercial, No-Derivatives License (CC BY-NC-ND; https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Mini-Review Stewart, Paul M Modified-Release Hydrocortisone: Is It Time to Change Clinical Practice? |
title | Modified-Release Hydrocortisone: Is It Time to Change Clinical Practice? |
title_full | Modified-Release Hydrocortisone: Is It Time to Change Clinical Practice? |
title_fullStr | Modified-Release Hydrocortisone: Is It Time to Change Clinical Practice? |
title_full_unstemmed | Modified-Release Hydrocortisone: Is It Time to Change Clinical Practice? |
title_short | Modified-Release Hydrocortisone: Is It Time to Change Clinical Practice? |
title_sort | modified-release hydrocortisone: is it time to change clinical practice? |
topic | Mini-Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532954/ https://www.ncbi.nlm.nih.gov/pubmed/31139761 http://dx.doi.org/10.1210/js.2019-00046 |
work_keys_str_mv | AT stewartpaulm modifiedreleasehydrocortisoneisittimetochangeclinicalpractice |