The antimalarial drug mefloquine enhances TP53 premature termination codon readthrough by aminoglycoside G418

Nonsense mutations constitute ~10% of TP53 mutations in cancer. They introduce a premature termination codon that gives rise to truncated p53 protein with impaired function. The aminoglycoside G418 can induce TP53 premature termination codon readthrough and thus increase cellular levels of full-leng...

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Detalles Bibliográficos
Autores principales: Ferguson, Michael W., Gerak, Chloe A. N., Chow, Christalle C. T., Rastelli, Ettore J., Elmore, Kyle E., Stahl, Florian, Hosseini-Farahabadi, Sara, Baradaran-Heravi, Alireza, Coltart, Don M., Roberge, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532957/
https://www.ncbi.nlm.nih.gov/pubmed/31120902
http://dx.doi.org/10.1371/journal.pone.0216423

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