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Delayed vaginal SHIV infection in VRC01 and anti-α4β7 treated rhesus macaques

VRC01 protects macaques from vaginal SHIV infection after a single high-dose challenge. Infusion of a simianized anti-α(4)β(7) mAb (Rh-α(4)β(7)) just prior to, and during repeated vaginal exposures to SIVmac251 partially protected macaques from vaginal SIV infection and rescued CD4(+) T cells. To in...

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Detalles Bibliográficos
Autores principales:	Calenda, Giulia, Frank, Ines, Arrode-Brusés, Géraldine, Pegu, Amarendra, Wang, Keyun, Arthos, James, Cicala, Claudia, Rogers, Kenneth A., Shirreff, Lisa, Grasperge, Brooke, Blanchard, James L., Maldonado, Stephanie, Roberts, Kevin, Gettie, Agegnehu, Villinger, Francois, Fauci, Anthony S., Mascola, John R., Martinelli, Elena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533011/ https://www.ncbi.nlm.nih.gov/pubmed/31083697 http://dx.doi.org/10.1371/journal.ppat.1007776

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