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Early-generated interneurons regulate neuronal circuit formation during early postnatal development
A small subset of interneurons that are generated earliest as pioneer neurons are the first cohort of neurons that enter the neocortex. However, it remains largely unclear whether these early-generated interneurons (EGIns) predominantly regulate neocortical circuit formation. Using inducible genetic...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533056/ https://www.ncbi.nlm.nih.gov/pubmed/31120418 http://dx.doi.org/10.7554/eLife.44649 |
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author | Wang, Chang-Zheng Ma, Jian Xu, Ye-Qian Jiang, Shao-Na Chen, Tian-Qi Yuan, Zu-Liang Mao, Xiao-Yi Zhang, Shu-Qing Liu, Lin-Yun Fu, Yinghui Yu, Yong-Chun |
author_facet | Wang, Chang-Zheng Ma, Jian Xu, Ye-Qian Jiang, Shao-Na Chen, Tian-Qi Yuan, Zu-Liang Mao, Xiao-Yi Zhang, Shu-Qing Liu, Lin-Yun Fu, Yinghui Yu, Yong-Chun |
author_sort | Wang, Chang-Zheng |
collection | PubMed |
description | A small subset of interneurons that are generated earliest as pioneer neurons are the first cohort of neurons that enter the neocortex. However, it remains largely unclear whether these early-generated interneurons (EGIns) predominantly regulate neocortical circuit formation. Using inducible genetic fate mapping to selectively label EGIns and pseudo-random interneurons (pRIns), we found that EGIns exhibited more mature electrophysiological and morphological properties and higher synaptic connectivity than pRIns in the somatosensory cortex at early postnatal stages. In addition, when stimulating one cell, the proportion of EGIns that influence spontaneous network synchronization is significantly higher than that of pRIns. Importantly, toxin-mediated ablation of EGIns after birth significantly reduce spontaneous network synchronization and decrease inhibitory synaptic formation during the first postnatal week. These results suggest that EGIns can shape developing networks and may contribute to the refinement of neuronal connectivity before the establishment of the adult neuronal circuit. |
format | Online Article Text |
id | pubmed-6533056 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-65330562019-05-28 Early-generated interneurons regulate neuronal circuit formation during early postnatal development Wang, Chang-Zheng Ma, Jian Xu, Ye-Qian Jiang, Shao-Na Chen, Tian-Qi Yuan, Zu-Liang Mao, Xiao-Yi Zhang, Shu-Qing Liu, Lin-Yun Fu, Yinghui Yu, Yong-Chun eLife Neuroscience A small subset of interneurons that are generated earliest as pioneer neurons are the first cohort of neurons that enter the neocortex. However, it remains largely unclear whether these early-generated interneurons (EGIns) predominantly regulate neocortical circuit formation. Using inducible genetic fate mapping to selectively label EGIns and pseudo-random interneurons (pRIns), we found that EGIns exhibited more mature electrophysiological and morphological properties and higher synaptic connectivity than pRIns in the somatosensory cortex at early postnatal stages. In addition, when stimulating one cell, the proportion of EGIns that influence spontaneous network synchronization is significantly higher than that of pRIns. Importantly, toxin-mediated ablation of EGIns after birth significantly reduce spontaneous network synchronization and decrease inhibitory synaptic formation during the first postnatal week. These results suggest that EGIns can shape developing networks and may contribute to the refinement of neuronal connectivity before the establishment of the adult neuronal circuit. eLife Sciences Publications, Ltd 2019-05-23 /pmc/articles/PMC6533056/ /pubmed/31120418 http://dx.doi.org/10.7554/eLife.44649 Text en © 2019, Wang et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Wang, Chang-Zheng Ma, Jian Xu, Ye-Qian Jiang, Shao-Na Chen, Tian-Qi Yuan, Zu-Liang Mao, Xiao-Yi Zhang, Shu-Qing Liu, Lin-Yun Fu, Yinghui Yu, Yong-Chun Early-generated interneurons regulate neuronal circuit formation during early postnatal development |
title | Early-generated interneurons regulate neuronal circuit formation during early postnatal development |
title_full | Early-generated interneurons regulate neuronal circuit formation during early postnatal development |
title_fullStr | Early-generated interneurons regulate neuronal circuit formation during early postnatal development |
title_full_unstemmed | Early-generated interneurons regulate neuronal circuit formation during early postnatal development |
title_short | Early-generated interneurons regulate neuronal circuit formation during early postnatal development |
title_sort | early-generated interneurons regulate neuronal circuit formation during early postnatal development |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533056/ https://www.ncbi.nlm.nih.gov/pubmed/31120418 http://dx.doi.org/10.7554/eLife.44649 |
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