An acquired scaffolding function of the DNAJ-PKAc fusion contributes to oncogenic signaling in fibrolamellar carcinoma

Fibrolamellar carcinoma (FLC) is a rare liver cancer. FLCs uniquely produce DNAJ-PKAc, a chimeric enzyme consisting of a chaperonin-binding domain fused to the Cα subunit of protein kinase A. Biochemical analyses of clinical samples reveal that a unique property of this fusion enzyme is the ability...

Descripción completa

Detalles Bibliográficos
Autores principales: Turnham, Rigney E, Smith, F Donelson, Kenerson, Heidi L, Omar, Mitchell H, Golkowski, Martin, Garcia, Irvin, Bauer, Renay, Lau, Ho-Tak, Sullivan, Kevin M, Langeberg, Lorene K, Ong, Shao-En, Riehle, Kimberly J, Yeung, Raymond S, Scott, John D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533061/
https://www.ncbi.nlm.nih.gov/pubmed/31063128
http://dx.doi.org/10.7554/eLife.44187

Ejemplares similares

Ejemplares similares