Novel RNA and DNA strand exchange activity of the PALB2 DNA binding domain and its critical role for DNA repair in cells

BReast Cancer Associated proteins 1 and 2 (BRCA1, −2) and Partner and Localizer of BRCA2 (PALB2) protein are tumour suppressors linked to a spectrum of malignancies, including breast cancer and Fanconi anemia. PALB2 coordinates functions of BRCA1 and BRCA2 during homology-directed repair (HDR) and i...

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Detalles Bibliográficos
Autores principales: Deveryshetty, Jaigeeth, Peterlini, Thibaut, Ryzhikov, Mikhail, Brahiti, Nadine, Dellaire, Graham, Masson, Jean-Yves, Korolev, Sergey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533086/
https://www.ncbi.nlm.nih.gov/pubmed/31017574
http://dx.doi.org/10.7554/eLife.44063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533086/
https://www.ncbi.nlm.nih.gov/pubmed/31017574
http://dx.doi.org/10.7554/eLife.44063

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