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A genetic variant rs13293512 in the promoter of let-7 is associated with an increased risk of breast cancer in Chinese women

Growing evidence has demonstrated that single-nucleotide polymorphisms (SNPs) in the promoter of miRNA may influence individuals’ susceptibility to human diseases. We examined two SNPs rs10877887 and rs13293512 in the promoters of let-7 family to determine if the two SNPs were related to the occurre...

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Autores principales: Sun, Ruifen, Gong, Jianyu, Li, Ju, Ruan, Zhiguo, Yang, Xiaomi, Zheng, Yongren, Qing, Lili, He, Xiaoshan, Jiang, Jike, Peng, Yanxia, Zou, Haijian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533205/
https://www.ncbi.nlm.nih.gov/pubmed/31028134
http://dx.doi.org/10.1042/BSR20182079
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author Sun, Ruifen
Gong, Jianyu
Li, Ju
Ruan, Zhiguo
Yang, Xiaomi
Zheng, Yongren
Qing, Lili
He, Xiaoshan
Jiang, Jike
Peng, Yanxia
Zou, Haijian
author_facet Sun, Ruifen
Gong, Jianyu
Li, Ju
Ruan, Zhiguo
Yang, Xiaomi
Zheng, Yongren
Qing, Lili
He, Xiaoshan
Jiang, Jike
Peng, Yanxia
Zou, Haijian
author_sort Sun, Ruifen
collection PubMed
description Growing evidence has demonstrated that single-nucleotide polymorphisms (SNPs) in the promoter of miRNA may influence individuals’ susceptibility to human diseases. We examined two SNPs rs10877887 and rs13293512 in the promoters of let-7 family to determine if the two SNPs were related to the occurrence of breast cancer (BC). Genotyping of the two SNPs was performed by PCR and restriction fragment length polymorphism analysis or TaqMan assay in 301 BC patients and 310 age matched controls. We found a higher frequency of rs13293512 CC genotype and rs13293512 C allele amongst BC patients (CC vs TT: adjusted odds ratio (OR) = 1.78; 95% CI: 1.14–2.80; P=0.012; C vs T: adjusted OR = 1.33; 95% CI: 1.06–1.67; P=0.013). Stratification analysis showed that rs13293512 CC genotype was associated with an increased risk of BC in patients with negative estrogen receptor (adjusted OR = 2.39; 95% CI: 1.32–4.30; P=0.004), patients with negative progesterone receptor (adjusted OR = 1.92; 95% CI: 1.11–3.33; P=0.02), patients with T1-2 stage cancer (adjusted OR = 1.77; 95% CI: 1.07–2.93; P=0.03), and patients with N1-3 stage cancer (adjusted OR = 1.89; 95% CI: 1.13–3.17; P=0.015). These findings suggest that rs13293512 in the promoter of let-7a-1/let-7f-1/let-7d cluster may be a possible biomarker for the development of BC in Chinese women.
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spelling pubmed-65332052019-05-30 A genetic variant rs13293512 in the promoter of let-7 is associated with an increased risk of breast cancer in Chinese women Sun, Ruifen Gong, Jianyu Li, Ju Ruan, Zhiguo Yang, Xiaomi Zheng, Yongren Qing, Lili He, Xiaoshan Jiang, Jike Peng, Yanxia Zou, Haijian Biosci Rep Research Articles Growing evidence has demonstrated that single-nucleotide polymorphisms (SNPs) in the promoter of miRNA may influence individuals’ susceptibility to human diseases. We examined two SNPs rs10877887 and rs13293512 in the promoters of let-7 family to determine if the two SNPs were related to the occurrence of breast cancer (BC). Genotyping of the two SNPs was performed by PCR and restriction fragment length polymorphism analysis or TaqMan assay in 301 BC patients and 310 age matched controls. We found a higher frequency of rs13293512 CC genotype and rs13293512 C allele amongst BC patients (CC vs TT: adjusted odds ratio (OR) = 1.78; 95% CI: 1.14–2.80; P=0.012; C vs T: adjusted OR = 1.33; 95% CI: 1.06–1.67; P=0.013). Stratification analysis showed that rs13293512 CC genotype was associated with an increased risk of BC in patients with negative estrogen receptor (adjusted OR = 2.39; 95% CI: 1.32–4.30; P=0.004), patients with negative progesterone receptor (adjusted OR = 1.92; 95% CI: 1.11–3.33; P=0.02), patients with T1-2 stage cancer (adjusted OR = 1.77; 95% CI: 1.07–2.93; P=0.03), and patients with N1-3 stage cancer (adjusted OR = 1.89; 95% CI: 1.13–3.17; P=0.015). These findings suggest that rs13293512 in the promoter of let-7a-1/let-7f-1/let-7d cluster may be a possible biomarker for the development of BC in Chinese women. Portland Press Ltd. 2019-05-24 /pmc/articles/PMC6533205/ /pubmed/31028134 http://dx.doi.org/10.1042/BSR20182079 Text en © 2019 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Articles
Sun, Ruifen
Gong, Jianyu
Li, Ju
Ruan, Zhiguo
Yang, Xiaomi
Zheng, Yongren
Qing, Lili
He, Xiaoshan
Jiang, Jike
Peng, Yanxia
Zou, Haijian
A genetic variant rs13293512 in the promoter of let-7 is associated with an increased risk of breast cancer in Chinese women
title A genetic variant rs13293512 in the promoter of let-7 is associated with an increased risk of breast cancer in Chinese women
title_full A genetic variant rs13293512 in the promoter of let-7 is associated with an increased risk of breast cancer in Chinese women
title_fullStr A genetic variant rs13293512 in the promoter of let-7 is associated with an increased risk of breast cancer in Chinese women
title_full_unstemmed A genetic variant rs13293512 in the promoter of let-7 is associated with an increased risk of breast cancer in Chinese women
title_short A genetic variant rs13293512 in the promoter of let-7 is associated with an increased risk of breast cancer in Chinese women
title_sort genetic variant rs13293512 in the promoter of let-7 is associated with an increased risk of breast cancer in chinese women
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533205/
https://www.ncbi.nlm.nih.gov/pubmed/31028134
http://dx.doi.org/10.1042/BSR20182079
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