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Ganoderic acid A attenuates lipopolysaccharide-induced lung injury in mice
The present study aimed to investigate the protective effects of ganoderic acid A (GAA) on lipopolysaccharide (LPS)-induced acute lung injury. In mouse model of LPS-induced acute lung injury, we found that GAA led to significantly lower lung wet-to-dry weight ratio and lung myeloperoxidase activity,...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533208/ https://www.ncbi.nlm.nih.gov/pubmed/31072918 http://dx.doi.org/10.1042/BSR20190301 |
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author | Wan, Bing Li, Yan Sun, Shuangshuang Yang, Yang LV, Yanling Wang, Li Song, Meijuan Chen, Meizi Wu, Chengjiang Pan, Hangcheng Zhang, Xiuwei |
author_facet | Wan, Bing Li, Yan Sun, Shuangshuang Yang, Yang LV, Yanling Wang, Li Song, Meijuan Chen, Meizi Wu, Chengjiang Pan, Hangcheng Zhang, Xiuwei |
author_sort | Wan, Bing |
collection | PubMed |
description | The present study aimed to investigate the protective effects of ganoderic acid A (GAA) on lipopolysaccharide (LPS)-induced acute lung injury. In mouse model of LPS-induced acute lung injury, we found that GAA led to significantly lower lung wet-to-dry weight ratio and lung myeloperoxidase activity, and attenuated pathological damages. In addition, GAA increased superoxide dismutase activity, but decreased malondialdehyde content and proinflammatory cytokines levels in the bronchoalveolar lavage fluid. Mechanistically, GAA reduced the activation of Rho/ROCK/NF-κB pathway to inhibit LPS-induced inflammation. In conclusion, our study suggests that GAA attenuates acute lung injury in mouse model via the inhibition of Rho/ROCK/NF-κB pathway. |
format | Online Article Text |
id | pubmed-6533208 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65332082019-05-30 Ganoderic acid A attenuates lipopolysaccharide-induced lung injury in mice Wan, Bing Li, Yan Sun, Shuangshuang Yang, Yang LV, Yanling Wang, Li Song, Meijuan Chen, Meizi Wu, Chengjiang Pan, Hangcheng Zhang, Xiuwei Biosci Rep Research Articles The present study aimed to investigate the protective effects of ganoderic acid A (GAA) on lipopolysaccharide (LPS)-induced acute lung injury. In mouse model of LPS-induced acute lung injury, we found that GAA led to significantly lower lung wet-to-dry weight ratio and lung myeloperoxidase activity, and attenuated pathological damages. In addition, GAA increased superoxide dismutase activity, but decreased malondialdehyde content and proinflammatory cytokines levels in the bronchoalveolar lavage fluid. Mechanistically, GAA reduced the activation of Rho/ROCK/NF-κB pathway to inhibit LPS-induced inflammation. In conclusion, our study suggests that GAA attenuates acute lung injury in mouse model via the inhibition of Rho/ROCK/NF-κB pathway. Portland Press Ltd. 2019-05-24 /pmc/articles/PMC6533208/ /pubmed/31072918 http://dx.doi.org/10.1042/BSR20190301 Text en © 2019 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Articles Wan, Bing Li, Yan Sun, Shuangshuang Yang, Yang LV, Yanling Wang, Li Song, Meijuan Chen, Meizi Wu, Chengjiang Pan, Hangcheng Zhang, Xiuwei Ganoderic acid A attenuates lipopolysaccharide-induced lung injury in mice |
title | Ganoderic acid A attenuates lipopolysaccharide-induced lung injury in mice |
title_full | Ganoderic acid A attenuates lipopolysaccharide-induced lung injury in mice |
title_fullStr | Ganoderic acid A attenuates lipopolysaccharide-induced lung injury in mice |
title_full_unstemmed | Ganoderic acid A attenuates lipopolysaccharide-induced lung injury in mice |
title_short | Ganoderic acid A attenuates lipopolysaccharide-induced lung injury in mice |
title_sort | ganoderic acid a attenuates lipopolysaccharide-induced lung injury in mice |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533208/ https://www.ncbi.nlm.nih.gov/pubmed/31072918 http://dx.doi.org/10.1042/BSR20190301 |
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