Deciphering the regulatory and catalytic mechanisms of an unusual SAM-dependent enzyme

S-adenosyl-1-methionine (SAM)-dependent enzymes regulate various disease-related behaviors in all organisms. Recently, the leporin biosynthesis enzyme LepI, a SAM-dependent enzyme, was reported to catalyze pericyclic reactions in leporin biosynthesis; however, the mechanisms underlying LepI activati...

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Detalles Bibliográficos
Autores principales: Sun, Qiu, Hu, Yuehong, Gu, Yijun, Huang, Jiangkun, He, Jun, Luo, Lan, Yang, Yi, Yin, Shuo, Dou, Chao, Wang, Tianqi, Fu, Xianghui, He, Ling, Qi, Shiqian, Zhu, Xiaofeng, Yang, Shengyong, Wei, Xiawei, Cheng, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533283/
https://www.ncbi.nlm.nih.gov/pubmed/31149354
http://dx.doi.org/10.1038/s41392-019-0052-y

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