Curcumin induces apoptosis in JAK2‐mutated cells by the inhibition of JAK2/STAT and mTORC1 pathways

Myeloproliferative neoplasms are chronic myeloid cancers divided in Philadelphia positive and negative. The JAK2 V617F is the most common mutation in Philadelphia negative patients and results in a constitutive activation of the JAK/STAT pathway, conferring a proliferative advantage and apoptosis in...

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Detalles Bibliográficos
Autores principales: Petiti, Jessica, Rosso, Valentina, Lo Iacono, Marco, Panuzzo, Cristina, Calabrese, Chiara, Signorino, Elisabetta, Pironi, Lucrezia, Cartellà, Antonio, Bracco, Enrico, Pergolizzi, Barbara, Beltramo, Tiziana, Fava, Carmen, Cilloni, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533565/
https://www.ncbi.nlm.nih.gov/pubmed/31033209
http://dx.doi.org/10.1111/jcmm.14326

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