Cargando…

Mitofusins: Disease Gatekeepers and Hubs in Mitochondrial Quality Control by E3 Ligases

Mitochondria are dynamic organelles engaged in quality control and aging processes. They constantly undergo fusion, fission, transport, and anchoring events, which empower mitochondria with a very interactive behavior. The membrane remodeling processes needed for fusion require conserved proteins na...

Descripción completa

Detalles Bibliográficos
Autores principales:	Escobar-Henriques, Mafalda, Joaquim, Mariana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533591/ https://www.ncbi.nlm.nih.gov/pubmed/31156446 http://dx.doi.org/10.3389/fphys.2019.00517

Ejemplares similares

E4 ubiquitin ligase promotes mitofusin turnover and mitochondrial stress response
por: Anton, Vincent, et al.
Publicado: (2023)

Role of Mitofusins and Mitophagy in Life or Death Decisions
por: Joaquim, Mariana, et al.
Publicado: (2020)

Mitochondrial Quality Control in Aging and Heart Failure: Influence of Ketone Bodies and Mitofusin-Stabilizing Peptides
por: Thai, Phung N., et al.
Publicado: (2019)

Mitofusin-2 Enhances Mitochondrial Contact With the Endoplasmic Reticulum and Promotes Diabetic Cardiomyopathy
por: Zhang, Jing, et al.
Publicado: (2021)

Mitofusin 2 Dysfunction and Disease in Mice and Men
por: Dorn, Gerald W.
Publicado: (2020)

Retraction: Mitofusin-2 enhances mitochondrial contact with the endoplasmic reticulum and promotes diabetic cardiomyopathy
Publicado: (2022)

Mitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic Target
por: Camara, Amadou K. S., et al.
Publicado: (2017)

Mitofusin 2 Participates in Mitophagy and Mitochondrial Fusion Against Angiotensin II-Induced Cardiomyocyte Injury
por: Xiong, Wenjun, et al.
Publicado: (2019)

Matrine Protects Cardiomyocytes Against Hyperglycemic Stress by Promoting Mitofusin 2-Induced Mitochondrial Fusion
por: Xiao, Tong, et al.
Publicado: (2021)

Retraction: Matrine protects cardiomyocytes against hyperglycemic stress by promoting mitofusin 2-induced mitochondrial fusion
Publicado: (2022)

Mitofusin 2 Is Essential for IP(3)-Mediated SR/Mitochondria Metabolic Feedback in Ventricular Myocytes
por: Seidlmayer, Lea K., et al.
Publicado: (2019)

E3 Ubiquitin Ligases in Neurological Diseases: Focus on Gigaxonin and Autophagy
por: Lescouzères, Léa, et al.
Publicado: (2020)

Modulating mitofusins to control mitochondrial function and signaling
por: Zacharioudakis, Emmanouil, et al.
Publicado: (2022)

Docking and stability defects in mitofusin highlight the proteasome as a potential therapeutic target
por: Buntenbroich, Ira, et al.
Publicado: (2023)

HECT E3 Ligases: A Tale With Multiple Facets
por: Weber, Janine, et al.
Publicado: (2019)

Editorial: E3 Ubiquitin Ligases: From Structure to Physiology
por: Licchesi, Julien D. F., et al.
Publicado: (2020)

E3 ubiquitin ligases in the acute leukemic signaling pathways
por: Zhan, Qianru, et al.
Publicado: (2022)

Plasticity in salt bridge allows fusion-competent ubiquitylation of mitofusins and Cdc48 recognition
por: Anton, Vincent, et al.
Publicado: (2019)

Dual role of a GTPase conformational switch for membrane fusion by mitofusin ubiquitylation
por: Schuster, Ramona, et al.
Publicado: (2019)

Controlling Parasympathetic Regulation of Heart Rate: A Gatekeeper Role for RGS Proteins in the Sinoatrial Node
por: Mighiu, Alexandra S., et al.
Publicado: (2012)

BK Channel Dysfunction in Diabetic Coronary Artery: Role of the E3 Ubiquitin Ligases
por: Qian, Ling-ling, et al.
Publicado: (2020)

Editorial: E3 ubiquitin ligases: From structure to physiology to therapeutics, Volume II
por: Licchesi, Julien D. F., et al.
Publicado: (2022)

TRAP1: A Metabolic Hub Linking Aging Pathophysiology to Mitochondrial S-Nitrosylation
por: Faienza, Fiorella, et al.
Publicado: (2020)

Mitochondrial Quality Control in Cardiac Diseases
por: Campos, Juliane C., et al.
Publicado: (2016)

Emerging Roles of the TRIM E3 Ubiquitin Ligases MID1 and MID2 in Cytokinesis
por: Zanchetta, Melania Eva, et al.
Publicado: (2019)

The regulatory roles of the E3 ubiquitin ligase NEDD4 family in DNA damage response
por: Lu, Xinxin, et al.
Publicado: (2022)

Mitochondrial fusion: Reaching the end of mitofusin’s tether
por: Formosa, Luke E., et al.
Publicado: (2016)

Gp78, an E3 Ubiquitin Ligase Acts as a Gatekeeper Suppressing Nonalcoholic Steatohepatitis (NASH) and Liver Cancer
por: Zhang, Tianpeng, et al.
Publicado: (2015)

Mitofusin 2 regulates the oocytes development and quality by modulating meiosis and mitochondrial function
por: Liu, Qun, et al.
Publicado: (2016)

Natural Killer Lytic-Associated Molecule (NKLAM): An E3 Ubiquitin Ligase With an Integral Role in Innate Immunity
por: Lawrence, Donald W., et al.
Publicado: (2020)

Dengue Virus Impairs Mitochondrial Fusion by Cleaving Mitofusins
por: Yu, Chia-Yi, et al.
Publicado: (2015)

Recent insights into the structure and function of Mitofusins in mitochondrial fusion
por: Cohen, Mickael M, et al.
Publicado: (2018)

Extracellular Regulated Kinase Phosphorylates Mitofusin 1 to Control Mitochondrial Morphology and Apoptosis
por: Pyakurel, Aswin, et al.
Publicado: (2015)

Mitochondria: hubs of cellular signaling, energetics and redox balance. A rich, vibrant, and diverse landscape of mitochondrial research
por: Aon, Miguel A., et al.
Publicado: (2015)

S100A4 as a Target of the E3-Ligase Asb2β and Its Effect on Engineered Heart Tissue
por: Braumann, Simon, et al.
Publicado: (2018)

Biochemical, biophysical, and functional characterisation of the E3 ubiquitin ligase APC/C regulator CDC20 from Arabidopsis thaliana
por: Cosma, Maria-Alexa, et al.
Publicado: (2022)

Mitochondrial Quality Control and Muscle Mass Maintenance
por: Romanello, Vanina, et al.
Publicado: (2016)

Mitochondrial Phenotypes in Genetically Diverse Neurodegenerative Diseases and Their Response to Mitofusin Activation
por: Dang, Xiawei, et al.
Publicado: (2022)

Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels
por: Mourier, Arnaud, et al.
Publicado: (2015)

Structures of human mitofusin 1 provide insight into mitochondrial tethering
por: Qi, Yuanbo, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_70iesric0vlft2e45b145ggudp