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Elevated PD-L1 expression predicts poor survival outcomes in patients with cervical cancer
BACKGROUND: Programmed cell death ligand 1 (PD-L1) expression has been shown to associate with poor prognosis in a variety of solid tumors. However, the prognostic value of PD-L1 expression in cervical cancer is still controversial. Therefore, we carried a meta-analysis to investigate the prognostic...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533692/ https://www.ncbi.nlm.nih.gov/pubmed/31143091 http://dx.doi.org/10.1186/s12935-019-0861-7 |
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author | Gu, Xiaobin Dong, Meilian Liu, Zheyan Mi, Yin Yang, Jing Zhang, Zhigang Liu, Ke Jiang, Li Zhang, Yue Dong, Shiliang Shi, Yonggang |
author_facet | Gu, Xiaobin Dong, Meilian Liu, Zheyan Mi, Yin Yang, Jing Zhang, Zhigang Liu, Ke Jiang, Li Zhang, Yue Dong, Shiliang Shi, Yonggang |
author_sort | Gu, Xiaobin |
collection | PubMed |
description | BACKGROUND: Programmed cell death ligand 1 (PD-L1) expression has been shown to associate with poor prognosis in a variety of solid tumors. However, the prognostic value of PD-L1 expression in cervical cancer is still controversial. Therefore, we carried a meta-analysis to investigate the prognostic and clinicopathological impact of PD-L1 in cervical cancer. METHODS: A comprehensive literature search in was performed in PubMed, Embase, Web of Science, and Cochrane Library. The correlation between PD-L1 expression and overall survival (OS), progression-free survival (PFS), and clinicopathological features was analyzed by hazard ratios (HR), odds ratios (OR) and corresponding 95% confidence intervals (CI). RESULTS: Seven studies with 783 patients were included in this meta-analysis. The combined HR and 95% CI of OS was 2.52 (1.09–5.83), p = 0.031. The pooled results for PFS were HR = 2.07, 95% CI = 0.52–8.23, p = 0.302. The results of subgroup analysis showed that PD-L1 was a significant prognostic factor of poor OS in Asian patients (HR = 4.77, 95% CI = 3.02–7.54, p < 0.001) and of poor PFS in Asian patients (HR = 4.78, 95% CI = 1.77–12.91, p = 0.002). However, the pooled results suggested that PD-L1 was not significantly correlated with lymph node metastasis, tumor size, FIGO stage, depth of invasion, lymph-vascular invasion, or age. CONCLUSIONS: The results of this meta-analysis suggest that PD-L1 overexpression is related to poor OS in patients with cervical cancer and poor PFS in Asian patients with cervical cancer. This study also suggests that PD-L1 is a promising prognostic indicator for cervical cancer. |
format | Online Article Text |
id | pubmed-6533692 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-65336922019-05-29 Elevated PD-L1 expression predicts poor survival outcomes in patients with cervical cancer Gu, Xiaobin Dong, Meilian Liu, Zheyan Mi, Yin Yang, Jing Zhang, Zhigang Liu, Ke Jiang, Li Zhang, Yue Dong, Shiliang Shi, Yonggang Cancer Cell Int Primary Research BACKGROUND: Programmed cell death ligand 1 (PD-L1) expression has been shown to associate with poor prognosis in a variety of solid tumors. However, the prognostic value of PD-L1 expression in cervical cancer is still controversial. Therefore, we carried a meta-analysis to investigate the prognostic and clinicopathological impact of PD-L1 in cervical cancer. METHODS: A comprehensive literature search in was performed in PubMed, Embase, Web of Science, and Cochrane Library. The correlation between PD-L1 expression and overall survival (OS), progression-free survival (PFS), and clinicopathological features was analyzed by hazard ratios (HR), odds ratios (OR) and corresponding 95% confidence intervals (CI). RESULTS: Seven studies with 783 patients were included in this meta-analysis. The combined HR and 95% CI of OS was 2.52 (1.09–5.83), p = 0.031. The pooled results for PFS were HR = 2.07, 95% CI = 0.52–8.23, p = 0.302. The results of subgroup analysis showed that PD-L1 was a significant prognostic factor of poor OS in Asian patients (HR = 4.77, 95% CI = 3.02–7.54, p < 0.001) and of poor PFS in Asian patients (HR = 4.78, 95% CI = 1.77–12.91, p = 0.002). However, the pooled results suggested that PD-L1 was not significantly correlated with lymph node metastasis, tumor size, FIGO stage, depth of invasion, lymph-vascular invasion, or age. CONCLUSIONS: The results of this meta-analysis suggest that PD-L1 overexpression is related to poor OS in patients with cervical cancer and poor PFS in Asian patients with cervical cancer. This study also suggests that PD-L1 is a promising prognostic indicator for cervical cancer. BioMed Central 2019-05-23 /pmc/articles/PMC6533692/ /pubmed/31143091 http://dx.doi.org/10.1186/s12935-019-0861-7 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Primary Research Gu, Xiaobin Dong, Meilian Liu, Zheyan Mi, Yin Yang, Jing Zhang, Zhigang Liu, Ke Jiang, Li Zhang, Yue Dong, Shiliang Shi, Yonggang Elevated PD-L1 expression predicts poor survival outcomes in patients with cervical cancer |
title | Elevated PD-L1 expression predicts poor survival outcomes in patients with cervical cancer |
title_full | Elevated PD-L1 expression predicts poor survival outcomes in patients with cervical cancer |
title_fullStr | Elevated PD-L1 expression predicts poor survival outcomes in patients with cervical cancer |
title_full_unstemmed | Elevated PD-L1 expression predicts poor survival outcomes in patients with cervical cancer |
title_short | Elevated PD-L1 expression predicts poor survival outcomes in patients with cervical cancer |
title_sort | elevated pd-l1 expression predicts poor survival outcomes in patients with cervical cancer |
topic | Primary Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533692/ https://www.ncbi.nlm.nih.gov/pubmed/31143091 http://dx.doi.org/10.1186/s12935-019-0861-7 |
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