The inherited variations of a p53-responsive enhancer in 13q12.12 confer lung cancer risk by attenuating TNFRSF19 expression

BACKGROUND: Inherited factors contribute to lung cancer risk, but the mechanism is not well understood. Defining the biological consequence of GWAS hits in cancers is a promising strategy to elucidate the inherited mechanisms of cancers. The tag-SNP rs753955 (A>G) in 13q12.12 is highly associated...

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Detalles Bibliográficos
Autores principales: Shao, Lipei, Zuo, Xianglin, Yang, Yin, Zhang, Yu, Yang, Nan, Shen, Bin, Wang, Jianying, Wang, Xuchun, Li, Ruilei, Jin, Guangfu, Yu, Dawei, Chen, Yuan, Sun, Luan, Li, Zhen, Fu, Qiaofen, Hu, Zhibin, Han, Xiao, Song, Xin, Shen, Hongbin, Sun, Yujie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533720/
https://www.ncbi.nlm.nih.gov/pubmed/31126313
http://dx.doi.org/10.1186/s13059-019-1696-1

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