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Polymorphism of the PPARD Gene and Dynamic Balance Performance in Han Chinese Children

BACKGROUND: Athletic performances are complex traits with heritability of ~66%. Dynamic balance is one of the most important athletic performances, and there has been little studies for it in sports genomics. The candidate PPARD gene was reported to be able to affect muscle development for balance p...

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Autores principales: Cao, Yixuan, Zhang, Qiyue, Chen, Jianhua, Li, Zhiqiang, Zhou, Zhaowei, Shen, Jiawei, Wang, Dong, Pan, Dun, Wang, Zhuo, Ke, Dandan, Wang, Xiaofei, Lu, Dajiang, Zhao, Ying, Cheng, Shulin, Shi, Yongyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533762/
https://www.ncbi.nlm.nih.gov/pubmed/31148953
http://dx.doi.org/10.1186/s41065-019-0092-x
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author Cao, Yixuan
Zhang, Qiyue
Chen, Jianhua
Li, Zhiqiang
Zhou, Zhaowei
Shen, Jiawei
Wang, Dong
Pan, Dun
Wang, Zhuo
Ke, Dandan
Wang, Xiaofei
Lu, Dajiang
Zhao, Ying
Cheng, Shulin
Shi, Yongyong
author_facet Cao, Yixuan
Zhang, Qiyue
Chen, Jianhua
Li, Zhiqiang
Zhou, Zhaowei
Shen, Jiawei
Wang, Dong
Pan, Dun
Wang, Zhuo
Ke, Dandan
Wang, Xiaofei
Lu, Dajiang
Zhao, Ying
Cheng, Shulin
Shi, Yongyong
author_sort Cao, Yixuan
collection PubMed
description BACKGROUND: Athletic performances are complex traits with heritability of ~66%. Dynamic balance is one of the most important athletic performances, and there has been little studies for it in sports genomics. The candidate PPARD gene was reported to be able to affect muscle development for balance predisposition and influence the athletic performance including skiing triumph in the Caucasian population. This study aims to investigate whether the PPARD gene is a susceptibility gene for dynamic balance performance in Han Chinese children. RESULTS: A total 2244 children were recruited and their balance beam performances were measured. Five polymorphisms in the PPARD gene were genotyped through the MassARRAY Sequenom platform. Rs2016520 exerted significant association with dynamic balance performance (minor allele C, P = 0.015, P(corrected) < 0.05) and was affirmed in a meta-analysis by combining previously reported Caucasian cohorts (OR = 1.57, 95% CI = [1.30, 1.91], P < 10 (-5)) . Another polymorphism, rs2267668, was also significantly associated with dynamic balance performance (minor allele G, P = 0.015, P(corrected) < 0.05). In the dichotomous study, 321 cases (61% boys and 39% girls) and 370 controls (49% boys and 51% girls) in our samples were selected as representatives, and the thresholds were the mean velocity (0.737 m/s) ± standard deviation (0.264 m/s), in which rs2016520-C and rs2267668-G still remained significant (CI =1.41 [1.11~1.79], P = 0.004, P(corrected) < 0.016; CI =1.45 [1.14~1.86], P = 0.002, P(corrected) < 0.016). In different genders, consistent OR direction was observed for each variant. CONCLUSIONS: Our results suggested that the PPARD gene is associated with dynamic balance performance of human being, and further studies to reveal its etiology is strongly suggested. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s41065-019-0092-x) contains supplementary material, which is available to authorized users.
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spelling pubmed-65337622019-05-30 Polymorphism of the PPARD Gene and Dynamic Balance Performance in Han Chinese Children Cao, Yixuan Zhang, Qiyue Chen, Jianhua Li, Zhiqiang Zhou, Zhaowei Shen, Jiawei Wang, Dong Pan, Dun Wang, Zhuo Ke, Dandan Wang, Xiaofei Lu, Dajiang Zhao, Ying Cheng, Shulin Shi, Yongyong Hereditas Research BACKGROUND: Athletic performances are complex traits with heritability of ~66%. Dynamic balance is one of the most important athletic performances, and there has been little studies for it in sports genomics. The candidate PPARD gene was reported to be able to affect muscle development for balance predisposition and influence the athletic performance including skiing triumph in the Caucasian population. This study aims to investigate whether the PPARD gene is a susceptibility gene for dynamic balance performance in Han Chinese children. RESULTS: A total 2244 children were recruited and their balance beam performances were measured. Five polymorphisms in the PPARD gene were genotyped through the MassARRAY Sequenom platform. Rs2016520 exerted significant association with dynamic balance performance (minor allele C, P = 0.015, P(corrected) < 0.05) and was affirmed in a meta-analysis by combining previously reported Caucasian cohorts (OR = 1.57, 95% CI = [1.30, 1.91], P < 10 (-5)) . Another polymorphism, rs2267668, was also significantly associated with dynamic balance performance (minor allele G, P = 0.015, P(corrected) < 0.05). In the dichotomous study, 321 cases (61% boys and 39% girls) and 370 controls (49% boys and 51% girls) in our samples were selected as representatives, and the thresholds were the mean velocity (0.737 m/s) ± standard deviation (0.264 m/s), in which rs2016520-C and rs2267668-G still remained significant (CI =1.41 [1.11~1.79], P = 0.004, P(corrected) < 0.016; CI =1.45 [1.14~1.86], P = 0.002, P(corrected) < 0.016). In different genders, consistent OR direction was observed for each variant. CONCLUSIONS: Our results suggested that the PPARD gene is associated with dynamic balance performance of human being, and further studies to reveal its etiology is strongly suggested. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s41065-019-0092-x) contains supplementary material, which is available to authorized users. BioMed Central 2019-05-23 /pmc/articles/PMC6533762/ /pubmed/31148953 http://dx.doi.org/10.1186/s41065-019-0092-x Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Cao, Yixuan
Zhang, Qiyue
Chen, Jianhua
Li, Zhiqiang
Zhou, Zhaowei
Shen, Jiawei
Wang, Dong
Pan, Dun
Wang, Zhuo
Ke, Dandan
Wang, Xiaofei
Lu, Dajiang
Zhao, Ying
Cheng, Shulin
Shi, Yongyong
Polymorphism of the PPARD Gene and Dynamic Balance Performance in Han Chinese Children
title Polymorphism of the PPARD Gene and Dynamic Balance Performance in Han Chinese Children
title_full Polymorphism of the PPARD Gene and Dynamic Balance Performance in Han Chinese Children
title_fullStr Polymorphism of the PPARD Gene and Dynamic Balance Performance in Han Chinese Children
title_full_unstemmed Polymorphism of the PPARD Gene and Dynamic Balance Performance in Han Chinese Children
title_short Polymorphism of the PPARD Gene and Dynamic Balance Performance in Han Chinese Children
title_sort polymorphism of the ppard gene and dynamic balance performance in han chinese children
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533762/
https://www.ncbi.nlm.nih.gov/pubmed/31148953
http://dx.doi.org/10.1186/s41065-019-0092-x
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