CD8(+) T cells regulate tumor ferroptosis during cancer immunotherapy

Cancer immunotherapy restores and/or enhances effector function of CD8(+) T cells in the tumor microenvironment(1,2). CD8(+) T cells activated by cancer immunotherapy execute tumor clearance mainly by inducing cell death through perforin-granzyme- and Fas/Fas ligand-pathways(3,4). Ferroptosis is a f...

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Detalles Bibliográficos
Autores principales: Wang, Weimin, Green, Michael, Choi, Jae Eun, Gijón, Miguel, Kennedy, Paul D., Johnson, Jeffrey K., Liao, Peng, Lang, Xueting, Kryczek, Ilona, Sell, Amanda, Xia, Houjun, Zhou, Jiajia, Li, Gaopeng, Li, Jing, Li, Wei, Wei, Shuang, Vatan, Linda, Zhang, Hongjuan, Szeliga, Wojciech, Gu, Wei, Liu, Rebecca, Lawrence, Theodore, Lamb, Candice, Tanno, Yuri, Cieslik, Marcin, Stone, Everett, Georgiou, George, Chan, Timothy A., Chinnaiyan, Arul, Zou, Weiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533917/
https://www.ncbi.nlm.nih.gov/pubmed/31043744
http://dx.doi.org/10.1038/s41586-019-1170-y

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