Cargando…

Phenytoin-induced bradycardia and hypotension

Phenytoin is an anticonvulsant which is also a Class IB antiarrhythmic. Its common adverse drug reactions (ADRs) include gastrointestinal symptoms, psychiatric disorders, gingival hyperplasia, and rash. Bradycardia and hypotension following intravenous (IV) phenytoin are rare ADRs. We report the cas...

Descripción completa

Detalles Bibliográficos
Autores principales: Mathews, Swetha Reba, Badyal, Dinesh Kumar, Mathew, Renji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533925/
https://www.ncbi.nlm.nih.gov/pubmed/31142948
http://dx.doi.org/10.4103/ijp.IJP_254_17
_version_ 1783421301323464704
author Mathews, Swetha Reba
Badyal, Dinesh Kumar
Mathew, Renji
author_facet Mathews, Swetha Reba
Badyal, Dinesh Kumar
Mathew, Renji
author_sort Mathews, Swetha Reba
collection PubMed
description Phenytoin is an anticonvulsant which is also a Class IB antiarrhythmic. Its common adverse drug reactions (ADRs) include gastrointestinal symptoms, psychiatric disorders, gingival hyperplasia, and rash. Bradycardia and hypotension following intravenous (IV) phenytoin are rare ADRs. We report the case of a 62-year-old female with subarachnoid hemorrhage and right bundle branch block, who developed sinus bradycardia and hypotension on administration of IV phenytoin. This case report serves as a note for caution on patient selection for the administration of phenytoin and highlights the need for specific guidelines on the same.
format Online
Article
Text
id pubmed-6533925
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-65339252019-05-29 Phenytoin-induced bradycardia and hypotension Mathews, Swetha Reba Badyal, Dinesh Kumar Mathew, Renji Indian J Pharmacol Drug Watch Phenytoin is an anticonvulsant which is also a Class IB antiarrhythmic. Its common adverse drug reactions (ADRs) include gastrointestinal symptoms, psychiatric disorders, gingival hyperplasia, and rash. Bradycardia and hypotension following intravenous (IV) phenytoin are rare ADRs. We report the case of a 62-year-old female with subarachnoid hemorrhage and right bundle branch block, who developed sinus bradycardia and hypotension on administration of IV phenytoin. This case report serves as a note for caution on patient selection for the administration of phenytoin and highlights the need for specific guidelines on the same. Wolters Kluwer - Medknow 2019 /pmc/articles/PMC6533925/ /pubmed/31142948 http://dx.doi.org/10.4103/ijp.IJP_254_17 Text en Copyright: © 2019 Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Drug Watch
Mathews, Swetha Reba
Badyal, Dinesh Kumar
Mathew, Renji
Phenytoin-induced bradycardia and hypotension
title Phenytoin-induced bradycardia and hypotension
title_full Phenytoin-induced bradycardia and hypotension
title_fullStr Phenytoin-induced bradycardia and hypotension
title_full_unstemmed Phenytoin-induced bradycardia and hypotension
title_short Phenytoin-induced bradycardia and hypotension
title_sort phenytoin-induced bradycardia and hypotension
topic Drug Watch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533925/
https://www.ncbi.nlm.nih.gov/pubmed/31142948
http://dx.doi.org/10.4103/ijp.IJP_254_17
work_keys_str_mv AT mathewsswethareba phenytoininducedbradycardiaandhypotension
AT badyaldineshkumar phenytoininducedbradycardiaandhypotension
AT mathewrenji phenytoininducedbradycardiaandhypotension