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Phenytoin-induced bradycardia and hypotension
Phenytoin is an anticonvulsant which is also a Class IB antiarrhythmic. Its common adverse drug reactions (ADRs) include gastrointestinal symptoms, psychiatric disorders, gingival hyperplasia, and rash. Bradycardia and hypotension following intravenous (IV) phenytoin are rare ADRs. We report the cas...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533925/ https://www.ncbi.nlm.nih.gov/pubmed/31142948 http://dx.doi.org/10.4103/ijp.IJP_254_17 |
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author | Mathews, Swetha Reba Badyal, Dinesh Kumar Mathew, Renji |
author_facet | Mathews, Swetha Reba Badyal, Dinesh Kumar Mathew, Renji |
author_sort | Mathews, Swetha Reba |
collection | PubMed |
description | Phenytoin is an anticonvulsant which is also a Class IB antiarrhythmic. Its common adverse drug reactions (ADRs) include gastrointestinal symptoms, psychiatric disorders, gingival hyperplasia, and rash. Bradycardia and hypotension following intravenous (IV) phenytoin are rare ADRs. We report the case of a 62-year-old female with subarachnoid hemorrhage and right bundle branch block, who developed sinus bradycardia and hypotension on administration of IV phenytoin. This case report serves as a note for caution on patient selection for the administration of phenytoin and highlights the need for specific guidelines on the same. |
format | Online Article Text |
id | pubmed-6533925 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-65339252019-05-29 Phenytoin-induced bradycardia and hypotension Mathews, Swetha Reba Badyal, Dinesh Kumar Mathew, Renji Indian J Pharmacol Drug Watch Phenytoin is an anticonvulsant which is also a Class IB antiarrhythmic. Its common adverse drug reactions (ADRs) include gastrointestinal symptoms, psychiatric disorders, gingival hyperplasia, and rash. Bradycardia and hypotension following intravenous (IV) phenytoin are rare ADRs. We report the case of a 62-year-old female with subarachnoid hemorrhage and right bundle branch block, who developed sinus bradycardia and hypotension on administration of IV phenytoin. This case report serves as a note for caution on patient selection for the administration of phenytoin and highlights the need for specific guidelines on the same. Wolters Kluwer - Medknow 2019 /pmc/articles/PMC6533925/ /pubmed/31142948 http://dx.doi.org/10.4103/ijp.IJP_254_17 Text en Copyright: © 2019 Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Drug Watch Mathews, Swetha Reba Badyal, Dinesh Kumar Mathew, Renji Phenytoin-induced bradycardia and hypotension |
title | Phenytoin-induced bradycardia and hypotension |
title_full | Phenytoin-induced bradycardia and hypotension |
title_fullStr | Phenytoin-induced bradycardia and hypotension |
title_full_unstemmed | Phenytoin-induced bradycardia and hypotension |
title_short | Phenytoin-induced bradycardia and hypotension |
title_sort | phenytoin-induced bradycardia and hypotension |
topic | Drug Watch |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533925/ https://www.ncbi.nlm.nih.gov/pubmed/31142948 http://dx.doi.org/10.4103/ijp.IJP_254_17 |
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