Gene expression profiling distinguishes prefibrotic from overtly fibrotic myeloproliferative neoplasms and identifies disease subsets with distinct inflammatory signatures

The Philadelphia chromosome-negative myeloproliferative neoplasms (MPN) share similar molecular characteristics in that they frequently harbor hotspot mutations in JAK2, CALR or MPL, leading to activated JAK/STAT signaling. However, these MPN have distinct symptoms, morphology, and natural histories...

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Detalles Bibliográficos
Autores principales: Wong, Waihay J., Baltay, Michele, Getz, Annaliese, Fuhrman, Kit, Aster, Jon C., Hasserjian, Robert P., Pozdnyakova, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534080/
https://www.ncbi.nlm.nih.gov/pubmed/31071164
http://dx.doi.org/10.1371/journal.pone.0216810

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