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Biological Characteristics of Cervical Precancerous Cell Proliferation

High-grade squamous intraepithelial lesions (HSILs) are regarded as precancerous lesions that can progress to cervical carcinoma; however, it is very difficult to effectively differentiate these precancerous cells from cancerous cells based on morphology alone. Additionally, the difference between p...

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Detalles Bibliográficos
Autores principales: Liu, Yuzhen, Cao, Chengcheng, Zhai, Peiling, Zhang, Youzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534105/
https://www.ncbi.nlm.nih.gov/pubmed/31157301
http://dx.doi.org/10.1515/med-2019-0036
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author Liu, Yuzhen
Cao, Chengcheng
Zhai, Peiling
Zhang, Youzhong
author_facet Liu, Yuzhen
Cao, Chengcheng
Zhai, Peiling
Zhang, Youzhong
author_sort Liu, Yuzhen
collection PubMed
description High-grade squamous intraepithelial lesions (HSILs) are regarded as precancerous lesions that can progress to cervical carcinoma; however, it is very difficult to effectively differentiate these precancerous cells from cancerous cells based on morphology alone. Additionally, the difference between precancerous cells and cancerous cells in regard to biological behaviour remains unclear. We previously cultured primary normal uterine cervical keratinocytes from human normal cervical tissue and cervical precancerous cells that were naturally infected with human papillomavirus from small-sized neoplastic cervical tissues. Here, we extended our study to further observe the in vitro proliferative characteristics of cervical precancerous cells at the cellular and molecular levels. In this study, we found that the growth rate of precancerous cells was significantly faster than that of normal cervical cells and slower than that of Caski cells. However, the proliferative capacity of such precancerous cells was similar to that of cancerous cells of the cervix at the molecular level. These results suggest that the surrounding environment of the cells may play an important role in the development of cervical cancer, which provides an important basis for the further study of precancerous and cancerous lesions of the cervix.
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spelling pubmed-65341052019-05-31 Biological Characteristics of Cervical Precancerous Cell Proliferation Liu, Yuzhen Cao, Chengcheng Zhai, Peiling Zhang, Youzhong Open Med (Wars) Research Article High-grade squamous intraepithelial lesions (HSILs) are regarded as precancerous lesions that can progress to cervical carcinoma; however, it is very difficult to effectively differentiate these precancerous cells from cancerous cells based on morphology alone. Additionally, the difference between precancerous cells and cancerous cells in regard to biological behaviour remains unclear. We previously cultured primary normal uterine cervical keratinocytes from human normal cervical tissue and cervical precancerous cells that were naturally infected with human papillomavirus from small-sized neoplastic cervical tissues. Here, we extended our study to further observe the in vitro proliferative characteristics of cervical precancerous cells at the cellular and molecular levels. In this study, we found that the growth rate of precancerous cells was significantly faster than that of normal cervical cells and slower than that of Caski cells. However, the proliferative capacity of such precancerous cells was similar to that of cancerous cells of the cervix at the molecular level. These results suggest that the surrounding environment of the cells may play an important role in the development of cervical cancer, which provides an important basis for the further study of precancerous and cancerous lesions of the cervix. De Gruyter 2019-05-11 /pmc/articles/PMC6534105/ /pubmed/31157301 http://dx.doi.org/10.1515/med-2019-0036 Text en © 2019 Yuzhen Liu et al., published by De Gruyter http://creativecommons.org/licenses/by-nc-nd/4.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.
spellingShingle Research Article
Liu, Yuzhen
Cao, Chengcheng
Zhai, Peiling
Zhang, Youzhong
Biological Characteristics of Cervical Precancerous Cell Proliferation
title Biological Characteristics of Cervical Precancerous Cell Proliferation
title_full Biological Characteristics of Cervical Precancerous Cell Proliferation
title_fullStr Biological Characteristics of Cervical Precancerous Cell Proliferation
title_full_unstemmed Biological Characteristics of Cervical Precancerous Cell Proliferation
title_short Biological Characteristics of Cervical Precancerous Cell Proliferation
title_sort biological characteristics of cervical precancerous cell proliferation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534105/
https://www.ncbi.nlm.nih.gov/pubmed/31157301
http://dx.doi.org/10.1515/med-2019-0036
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