Ubiquilins Regulate Autophagic Flux through mTOR Signaling and Lysosomal Acidification

Although the etiology of ALS remains poorly understood, impaired proteostasis is a common feature of different forms of ALS. Mutations in Ubiquilins, UBQLN2 and UBQLN4, cause familial ALS. The role of UBQLNs in proteasomal degradation is well established but their role in autophagy-lysosomal clearan...

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Detalles Bibliográficos
Autores principales: Şentürk, Mümine, Lin, Guang, Zuo, Zhongyuan, Mao, Dongxue, Watson, Emma, Mikos, Antonios G., Bellen, Hugo J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534127/
https://www.ncbi.nlm.nih.gov/pubmed/30804504
http://dx.doi.org/10.1038/s41556-019-0281-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534127/
https://www.ncbi.nlm.nih.gov/pubmed/30804504
http://dx.doi.org/10.1038/s41556-019-0281-x

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