Cargando…

Exploring the mucoadhesive behavior of sucrose acetate isobutyrate: a novel excipient for oral delivery of biopharmaceuticals

Oral drug delivery is an attractive noninvasive alternative to injectables. However, oral delivery of biopharmaceuticals is highly challenging due to low stability during transit in the gastrointestinal tract (GIT), resulting in low systemic bioavailability. Thus, novel formulation strategies are es...

Descripción completa

Detalles Bibliográficos
Autores principales:	Harloff-Helleberg, Stine, Fliervoet, Lies A. L., Fanø, Mathias, Schmitt, Mechthild, Antopolski, Maxim, Urtti, Arto, Nielsen, Hanne Mørck
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534213/ https://www.ncbi.nlm.nih.gov/pubmed/31090468 http://dx.doi.org/10.1080/10717544.2019.1606866

Ejemplares similares

Mucoadhesive Dendrons Conjugated to Mesoporous Silica Nanoparticles as a Drug Delivery Approach for Orally Administered Biopharmaceuticals
por: Tollemeto, Matteo, et al.
Publicado: (2023)

Application of Sucrose Acetate Isobutyrate in Development of Co-Amorphous Formulations of Tacrolimus for Bioavailability Enhancement
por: Mohamed, Eman M., et al.
Publicado: (2023)

Controlled released naringin-loaded liposome/sucrose acetate isobutyrate hybrid depot for osteogenesis in vitro and in vivo
por: Meng, Di, et al.
Publicado: (2023)

Delivery of radix ophiopogonis polysaccharide via sucrose acetate isobutyrate-based in situ forming systems alone or combined with its mono-PEGylation
por: Wang, LiNa, et al.
Publicado: (2018)

Mucoadhesive Gelatin Buccal Films with Propranolol Hydrochloride: Evaluation of Mechanical, Mucoadhesive, and Biopharmaceutical Properties
por: Jovanović, Marija, et al.
Publicado: (2021)

Electrospun naringin-loaded microsphere/sucrose acetate isobutyrate system promotes macrophage polarization toward M2 and facilitates osteoporotic bone defect repair
por: Li, Jihong, et al.
Publicado: (2023)

Safety and Biopharmaceutical Challenges of Excipients in Off-Label Pediatric Formulations
por: Belayneh, Anteneh, et al.
Publicado: (2020)

Intraoral Drug Delivery: Highly Thiolated κ-Carrageenan as Mucoadhesive Excipient
por: Kali, Gergely, et al.
Publicado: (2023)

Effects of polyol excipient stability during storage and use on the quality of biopharmaceutical formulations
por: Sun, Min-Fei, et al.
Publicado: (2022)

Mucoadhesive Electrospun Nanofiber-Based Hybrid System with Controlled and Unidirectional Release of Desmopressin
por: Stie, Mai Bay, et al.
Publicado: (2022)

Genotoxicity evaluation of magnesium salts of isobutyrate and 2-methylbutyrate
por: Dolan, Laurie C., et al.
Publicado: (2021)

Comprehensive Assessment of Protein and Excipient Stability in Biopharmaceutical Formulations Using (1)H NMR Spectroscopy
por: Bramham, Jack E., et al.
Publicado: (2020)

Post-synthesis nanostructuration of BSA-Capsaicin nanoparticles generated by sucrose excipient
por: Carriles, Ramón, et al.
Publicado: (2021)

Effects of Sucrose Palmitate on the Physico-Chemical and Mucoadhesive Properties of Buccal Films
por: Kelemen, András, et al.
Publicado: (2020)

Anionic and Ampholytic High-Amylose Starch Derivatives as Excipients for Pharmaceutical and Biopharmaceutical Applications: Structure-Properties Correlations
por: Labelle, Marc-André, et al.
Publicado: (2023)

Thiolated 2-Methyl-β-Cyclodextrin as a Mucoadhesive Excipient for Poorly Soluble Drugs: Synthesis and Characterization
por: Grassiri, Brunella, et al.
Publicado: (2022)

Biopharmaceutical Understanding of Excipient Variability on Drug Apparent Solubility Based on Drug Physicochemical Properties. Case Study: Superdisintegrants
por: Zarmpi, Panagiota, et al.
Publicado: (2020)

Synthesis and Characterization of Thiolated Gum Ghatti as a Novel Excipient: Development of Compression-Coated Mucoadhesive Tablets of Domperidone
por: Puri, Vivek, et al.
Publicado: (2021)

Biopharmaceutical Understanding of Excipient Variability on Drug Apparent Solubility Based on Drug Physicochemical Properties: Case Study—Hypromellose (HPMC)
por: Zarmpi, P., et al.
Publicado: (2020)

Gel Volume Near the Critical Point of Binary Mixture Isobutyric Acid–Water
por: Yamamoto, Takao, et al.
Publicado: (2020)

Isobutyric acid promotes colorectal cancer metastasis through activating RACK1
por: Chen, Jinglian, et al.
Publicado: (2023)

Cyclodextrin and its derivatives as effective excipients for amorphous ulipristal acetate systems
por: Wang, Peng, et al.
Publicado: (2022)

Production of a newly discovered PHA family member with an isobutyrate-fed enrichment culture
por: Vermeer, Chris M., et al.
Publicado: (2022)

Dietary Patterns, Fiber Intake and Microbial-Derived Isobutyrate Are Associated With Executive Function in Toddlerhood
por: McMath, Arden, et al.
Publicado: (2022)

Biopharmaceutics of Topical Ophthalmic Suspensions: Importance of Viscosity and Particle Size in Ocular Absorption of Indomethacin
por: Toropainen, Elisa, et al.
Publicado: (2021)

Effect of the Similarity of Formulations and Excipients of Approved Generic Drug Products on In Vivo Bioequivalence for Putative Biopharmaceutics Classification System Class III Drugs
por: Ren, Ping, et al.
Publicado: (2023)

Excipients
Publicado: (1878)

Low Acyl Gellan as an Excipient to Improve the Sprayability and Mucoadhesion of Iota Carrageenan in a Nasal Spray to Prevent Infection With SARS-CoV-2
por: Robinson, Thomas E., et al.
Publicado: (2021)

Optical catapulting of microspheres in mucus models—toward overcoming the mucus biobarrier
por: Bunea, Ada-Ioana, et al.
Publicado: (2019)

Heterofunctional Poly(ethylene glycol) (PEG) Macroinitiator Enabling Controlled Synthesis of ABC Triblock Copolymers
por: Fliervoet, Lies A. L., et al.
Publicado: (2017)

Mucoadhesive Electrospun Patch Delivery of Lidocaine to the Oral Mucosa and Investigation of Spatial Distribution in a Tissue Using MALDI-Mass Spectrometry Imaging
por: Clitherow, Katharina H., et al.
Publicado: (2019)

Glycerine as an Excipient
Publicado: (1885)

Lanolin as an Excipient
Publicado: (1907)

Biopharmaceutical Assessment of Dexamethasone Acetate-Based Hydrogels Combining Hydroxypropyl Cyclodextrins and Polysaccharides for Ocular Delivery
por: Mazet, Roseline, et al.
Publicado: (2020)

Biopharmaceuticals : biochemistry and biotechnology
por: Walsh, Gary
Publicado: (2003)

Biopharmaceuticals : biochemistry and biotechnology /
por: Walsh, Gary
Publicado: (1998)

Metabolic engineering of Pseudomonas sp. strain VLB120 as platform biocatalyst for the production of isobutyric acid and other secondary metabolites
por: Lang, Karsten, et al.
Publicado: (2014)

Handbook of pharmaceutical excipients.
Publicado: (2003)

Excipient for External Application
Publicado: (1890)

Anaphylaxis to drug excipients
por: Pfützner, Wolfgang
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ns8qei06p9tck8g0bannegojti