Locally injected ivabradine inhibits carrageenan-induced pain and inflammatory responses via hyperpolarization-activated cyclic nucleotide-gated (HCN) channels

BACKGROUND: Recently, attention has been focused on the role of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the mechanism of and as a treatment target for neuropathic and inflammatory pain. Ivabradine, a blocker of HCN channels, was demonstrated to have an effect on neuropa...

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Detalles Bibliográficos
Autores principales: Miyake, Saki, Higuchi, Hitoshi, Honda-Wakasugi, Yuka, Fujimoto, Maki, Kawai, Hotaka, Nagatsuka, Hitoshi, Maeda, Shigeru, Miyawaki, Takuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534329/
https://www.ncbi.nlm.nih.gov/pubmed/31125368
http://dx.doi.org/10.1371/journal.pone.0217209

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