Inhibition of DUSP6 sensitizes ovarian cancer cells to chemotherapeutic agents via regulation of ERK signaling response genes

Dual specificity phosphatase 6 (DUSP6) is a protein phosphatase that deactivates extracellular-signal-regulated kinase (ERK). Since the ovarian cancer biomarker human epididymis protein 4 (HE4) interacts with the ERK pathway, we sought to determine the relationship between DUSP6 and HE4 and elucidat...

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Detalles Bibliográficos
Autores principales: James, Nicole E., Beffa, Lindsey, Oliver, Matthew T., Borgstadt, Ashley D., Emerson, Jenna B., Chichester, Clinton O., Yano, Naohiro, Freiman, Richard N., DiSilvestro, Paul A., Ribeiro, Jennifer R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534361/
https://www.ncbi.nlm.nih.gov/pubmed/31164954

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