Absence of PD-L1 expression on tumor cells in the context of an activated immune infiltrate may indicate impaired IFNγ signaling in non-small cell lung cancer

BACKGROUND: In non-small cell lung cancer (NSCLC), PD-L1 expression on either tumor cells (TC) or both TC and tumor-infiltrating immune cells (IC) is currently the most used biomarker in cancer immunotherapy. However, the mechanisms involved in PD-L1 regulation are not fully understood. To provide b...

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Detalles Bibliográficos
Autores principales: Theelen, Willemijn S. M. E., Kuilman, Thomas, Schulze, Katja, Zou, Wei, Krijgsman, Oscar, Peters, Dennis D. G. C., Cornelissen, Sten, Monkhorst, Kim, Sarma, Pranamee, Sumiyoshi, Teiko, Amler, Lukas C., Willems, Stefan M., Blaauwgeers, Johannes L. G., van Noesel, Carel J. M., Peeper, Daniel S., van den Heuvel, Michel M., Kowanetz, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534376/
https://www.ncbi.nlm.nih.gov/pubmed/31125352
http://dx.doi.org/10.1371/journal.pone.0216864

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