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A novel hydrolase with a pro-death activity from the protozoan parasite Leishmania major

Apoptosis is a cell death process generally described as involving a cascade of caspase activation, death receptors and/or pro- and antiapoptotic molecules from the BcL-2 family. But about 20 years ago, a caspase-independent apoptotic pathway has been described. Regarding this pathway, we can learn...

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Autores principales: Basmaciyan, Louise, Jacquet, Pauline, Azas, Nadine, Casanova, Magali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534544/
https://www.ncbi.nlm.nih.gov/pubmed/31149349
http://dx.doi.org/10.1038/s41420-019-0178-2
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author Basmaciyan, Louise
Jacquet, Pauline
Azas, Nadine
Casanova, Magali
author_facet Basmaciyan, Louise
Jacquet, Pauline
Azas, Nadine
Casanova, Magali
author_sort Basmaciyan, Louise
collection PubMed
description Apoptosis is a cell death process generally described as involving a cascade of caspase activation, death receptors and/or pro- and antiapoptotic molecules from the BcL-2 family. But about 20 years ago, a caspase-independent apoptotic pathway has been described. Regarding this pathway, we can learn a lot from Leishmania parasites. Indeed, these parasitic protozoa enter, in response to different stimuli, in a form of cell death phenotypically similar to mammalian apoptosis but without involving caspases or death receptors. So far, only two proteins have been clearly identified as being involved in Leishmania-regulated cell death: the metacaspase and the endonuclease G. We report here the identification of a new protein modeled as a potential hydrolase, highly conserved among Leishmania species and absent in the very close parasite Trypanosoma brucei. This protein is involved in L. major-regulated cell death induced by curcumin, miltefosine and pentamidine, after gene overexpression and/or protein translocation to the nucleus. The identification of proteins involved in Leishmania-regulated cell death will provide a better understanding of nonconventional apoptotic pathways in higher eukaryotes. It will also allow the development of new therapeutic tools via the identification of new specific targets.
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spelling pubmed-65345442019-05-30 A novel hydrolase with a pro-death activity from the protozoan parasite Leishmania major Basmaciyan, Louise Jacquet, Pauline Azas, Nadine Casanova, Magali Cell Death Discov Review Article Apoptosis is a cell death process generally described as involving a cascade of caspase activation, death receptors and/or pro- and antiapoptotic molecules from the BcL-2 family. But about 20 years ago, a caspase-independent apoptotic pathway has been described. Regarding this pathway, we can learn a lot from Leishmania parasites. Indeed, these parasitic protozoa enter, in response to different stimuli, in a form of cell death phenotypically similar to mammalian apoptosis but without involving caspases or death receptors. So far, only two proteins have been clearly identified as being involved in Leishmania-regulated cell death: the metacaspase and the endonuclease G. We report here the identification of a new protein modeled as a potential hydrolase, highly conserved among Leishmania species and absent in the very close parasite Trypanosoma brucei. This protein is involved in L. major-regulated cell death induced by curcumin, miltefosine and pentamidine, after gene overexpression and/or protein translocation to the nucleus. The identification of proteins involved in Leishmania-regulated cell death will provide a better understanding of nonconventional apoptotic pathways in higher eukaryotes. It will also allow the development of new therapeutic tools via the identification of new specific targets. Nature Publishing Group UK 2019-05-24 /pmc/articles/PMC6534544/ /pubmed/31149349 http://dx.doi.org/10.1038/s41420-019-0178-2 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Basmaciyan, Louise
Jacquet, Pauline
Azas, Nadine
Casanova, Magali
A novel hydrolase with a pro-death activity from the protozoan parasite Leishmania major
title A novel hydrolase with a pro-death activity from the protozoan parasite Leishmania major
title_full A novel hydrolase with a pro-death activity from the protozoan parasite Leishmania major
title_fullStr A novel hydrolase with a pro-death activity from the protozoan parasite Leishmania major
title_full_unstemmed A novel hydrolase with a pro-death activity from the protozoan parasite Leishmania major
title_short A novel hydrolase with a pro-death activity from the protozoan parasite Leishmania major
title_sort novel hydrolase with a pro-death activity from the protozoan parasite leishmania major
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534544/
https://www.ncbi.nlm.nih.gov/pubmed/31149349
http://dx.doi.org/10.1038/s41420-019-0178-2
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