Cargando…

Systems Pharmacogenomic Landscape of Drug Similarities from LINCS data: Drug Association Networks

Modern research in the biomedical sciences is data-driven utilizing high-throughput technologies to generate big genomic data. The Library of Integrated Network-based Cellular Signatures (LINCS) is an example for a large-scale genomic data repository providing hundred thousands of high-dimensional g...

Descripción completa

Detalles Bibliográficos
Autores principales:	Musa, Aliyu, Tripathi, Shailesh, Dehmer, Matthias, Yli-Harja, Olli, Kauffman, Stuart A., Emmert-Streib, Frank
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534546/ https://www.ncbi.nlm.nih.gov/pubmed/31127155 http://dx.doi.org/10.1038/s41598-019-44291-3

Ejemplares similares

L1000 Viewer: A Search Engine and Web Interface for the LINCS Data Repository
por: Musa, Aliyu, et al.
Publicado: (2019)

Harnessing the biological complexity of Big Data from LINCS gene expression signatures
por: Musa, Aliyu, et al.
Publicado: (2018)

Graph-based exploitation of gene ontology using GOxploreR for scrutinizing biological significance
por: Manjang, Kalifa, et al.
Publicado: (2020)

Global Genetics Research in Prostate Cancer: A Text Mining and Computational Network Theory Approach
por: Azam, Md. Facihul, et al.
Publicado: (2019)

sgnesR: An R package for simulating gene expression data from an underlying real gene network structure considering delay parameters
por: Tripathi, Shailesh, et al.
Publicado: (2017)

Prognostic gene expression signatures of breast cancer are lacking a sensible biological meaning
por: Manjang, Kalifa, et al.
Publicado: (2021)

Against Dataism and for Data Sharing of Big Biomedical and Clinical Data with Research Parasites
por: Emmert-Streib, Frank, et al.
Publicado: (2016)

Lessons from the Human Genome Project: Modesty, Honesty, and Realism
por: Emmert-Streib, Frank, et al.
Publicado: (2017)

Utilizing Social Media Data for Psychoanalysis to Study Human Personality
por: Emmert-Streib, Frank, et al.
Publicado: (2019)

Ensuring Quality Standards and Reproducible Research for Data Analysis Services in Oncology: A Cooperative Service Model
por: Emmert-Streib, Frank, et al.
Publicado: (2019)

Artificial Intelligence: A Clarification of Misconceptions, Myths and Desired Status
por: Emmert-Streib, Frank, et al.
Publicado: (2020)

Data Analytics Applications for Streaming Data From Social Media: What to Predict?
por: Emmert-Streib, Frank, et al.
Publicado: (2018)

Combining deep learning with token selection for patient phenotyping from electronic health records
por: Yang, Zhen, et al.
Publicado: (2020)

Limitations of Explainability for Established Prognostic Biomarkers of Prostate Cancer
por: Manjang, Kalifa, et al.
Publicado: (2021)

Are There Limits in Explainability of Prognostic Biomarkers? Scrutinizing Biological Utility of Established Signatures
por: Emmert-Streib, Frank, et al.
Publicado: (2021)

What Is a Digital Twin? Experimental Design for a Data-Centric Machine Learning Perspective in Health
por: Emmert-Streib, Frank, et al.
Publicado: (2022)

Alkylaminophenol Induces G1/S Phase Cell Cycle Arrest in Glioblastoma Cells Through p53 and Cyclin-Dependent Kinase Signaling Pathway
por: Doan, Phuong, et al.
Publicado: (2019)

Large-Scale Evaluation of Molecular Descriptors by Means of Clustering
por: Dehmer, Matthias, et al.
Publicado: (2013)

The Need for Formally Defining “Modern Medicine” by Means of Experimental Design
por: Emmert-Streib, Frank, et al.
Publicado: (2016)

Comparison of module detection algorithms in protein networks and investigation of the biological meaning of predicted modules
por: Tripathi, Shailesh, et al.
Publicado: (2016)

Discrimination Power of Polynomial-Based Descriptors for Graphs by Using Functional Matrices
por: Dehmer, Matthias, et al.
Publicado: (2015)

An Introductory Review of Deep Learning for Prediction Models With Big Data
por: Emmert-Streib, Frank, et al.
Publicado: (2020)

Glioblastoma Multiforme Stem Cell Cycle Arrest by Alkylaminophenol through the Modulation of EGFR and CSC Signaling Pathways
por: Doan, Phuong, et al.
Publicado: (2020)

Analysis of complex networks: from biology to linguistics
por: Dehmer, Matthias, et al.
Publicado: (2009)

Exploring Statistical and Population Aspects of Network Complexity
por: Emmert-Streib, Frank, et al.
Publicado: (2012)

Influence of the Time Scale on the Construction of Financial Networks
por: Emmert-Streib, Frank, et al.
Publicado: (2010)

Biological networks: the microscope of the twenty-first century?
por: Emmert-Streib, Frank, et al.
Publicado: (2015)

Information processing in the transcriptional regulatory network of yeast: Functional robustness
por: Emmert-Streib, Frank, et al.
Publicado: (2009)

Ensuring the Robustness and Reliability of Data-Driven Knowledge Discovery Models in Production and Manufacturing
por: Tripathi, Shailesh, et al.
Publicado: (2021)

Data-Driven Computational Social Network Science: Predictive and Inferential Models for Web-Enabled Scientific Discoveries
por: Emmert-Streib, Frank, et al.
Publicado: (2021)

A Bayesian analysis of the chromosome architecture of human disorders by integrating reductionist data
por: Emmert-Streib, Frank, et al.
Publicado: (2012)

The gene regulatory network for breast cancer: integrated regulatory landscape of cancer hallmarks
por: Emmert-Streib, Frank, et al.
Publicado: (2014)

Entropy Bounds for Hierarchical Molecular Networks
por: Dehmer, Matthias, et al.
Publicado: (2008)

Towards an Information Theory of Complex Networks
por: Dehmer, Matthias, et al.
Publicado: (2011)

Connections between Classical and Parametric Network Entropies
por: Dehmer, Matthias, et al.
Publicado: (2011)

Quantitative graph theory: mathematical foundations and applications
por: Dehmer, Matthias, et al.
Publicado: (2014)

Predicting Cell Cycle Regulated Genes by Causal Interactions
por: Emmert-Streib, Frank, et al.
Publicado: (2009)

Hierarchical coordination of periodic genes in the cell cycle of Saccharomyces cerevisiae
por: Emmert-Streib, Frank, et al.
Publicado: (2009)

Enhancing systems medicine beyond genotype data by dynamic patient signatures: having information and using it too
por: Emmert-Streib, Frank, et al.
Publicado: (2013)

Comparing deep belief networks with support vector machines for classifying gene expression data from complex disorders
por: Smolander, Johannes, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_8qiq11gbkh1sj6h6esbghjitdn