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Oridonin protects against cardiac hypertrophy by promoting P21-related autophagy
Autophagy is an endogenous protective process; the loss of autophagy could destabilize proteostasis and elevate intracellular oxidative stress, which is critically involved in the development of cardiac hypertrophy and heart failure. Oridonin, a natural tetracycline diterpenoid from the Chinese herb...
Autores principales: | Xu, Man, Wan, Chun-xia, Huang, Si-hui, Wang, Hui-bo, Fan, Di, Wu, Hai-Ming, Wu, Qing-qing, Ma, Zhen-guo, Deng, Wei, Tang, Qi-Zhu |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534559/ https://www.ncbi.nlm.nih.gov/pubmed/31127082 http://dx.doi.org/10.1038/s41419-019-1617-y |
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