Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF

Histone methyltransferase MLL4 is centrally involved in transcriptional regulation and is often mutated in human diseases, including cancer and developmental disorders. MLL4 contains a catalytic SET domain that mono-methylates histone H3K4 and seven PHD fingers of unclear function. Here, we identify...

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Detalles Bibliográficos
Autores principales: Zhang, Yi, Jang, Younghoon, Lee, Ji-Eun, Ahn, JaeWoo, Xu, Longxia, Holden, Michael R., Cornett, Evan M., Krajewski, Krzysztof, Klein, Brianna J., Wang, Shu-Ping, Dou, Yali, Roeder, Robert G., Strahl, Brian D., Rothbart, Scott B., Shi, Xiaobing, Ge, Kai, Kutateladze, Tatiana G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534582/
https://www.ncbi.nlm.nih.gov/pubmed/31127101
http://dx.doi.org/10.1038/s41467-019-10324-8

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